Allen Sharon, Harrison Katherine, Petersen Ashley, Goodson Jane
Tobacco Research Programs, Department of Family Medicine & Community Health, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN, 55414, USA.
Division of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.
BMC Res Notes. 2019 Aug 1;12(1):473. doi: 10.1186/s13104-019-4503-x.
Current literature suggests there may be a relationship between sex hormones, which dramatically increase during pregnancy, and nicotine use behaviors. We hypothesized that higher progesterone and progesterone:estradiol ratio (P/E) would be associated with less smoking-related symptomatology (SRS), better mood and fewer cigarettes smoked per day (CPD) during ad libitum smoking and following overnight abstinence in pregnant women. Associations between SRS, mood, smoking behavior and sex hormones were estimated using multiple linear regression with adjustment for CPD and pregnancy trimester.
There were 35 second trimester and 42 third trimester participants. Participants mean age was 26.2 (SD: 4.1), they smoked 11.3 CPD (SD: 4.4) and the mean nicotine dependence score was 4.94 (SD: 1.98). There were no statistically significant associations between progesterone levels, estradiol levels, or the P/E ratio and SRS or mood measures during ad libitum smoking or following overnight abstinence in this sample of pregnant women. Similarly, there were no associations between sex hormone levels and number of CPD smoked during the ad libitum period. Contrary to our hypothesis, we found no significant associations between sex hormones and SRS, mood or smoking behavior in this sample of pregnant women. Trial registration ClinicalTrials.gov (NCT01811225), December 6, 2012.
当前文献表明，孕期大幅增加的性激素与尼古丁使用行为之间可能存在关联。我们假设，较高的孕酮水平及孕酮与雌二醇的比值（P/E）与孕妇在随意吸烟期间及过夜戒烟后较少的吸烟相关症状（SRS）、更好的情绪状态以及更低的每日吸烟量（CPD）相关。使用多元线性回归评估SRS、情绪、吸烟行为与性激素之间的关联，并对CPD和妊娠 trimester进行调整。
共有35名孕中期参与者和42名孕晚期参与者。参与者的平均年龄为26.2岁（标准差：4.1），他们的每日吸烟量为11.3支（标准差：4.4），平均尼古丁依赖评分为4.94（标准差：1.98）。在该孕妇样本中，无论是随意吸烟期间还是过夜戒烟后，孕酮水平、雌二醇水平或P/E比值与SRS或情绪指标之间均无统计学上的显著关联。同样，性激素水平与随意吸烟期间的CPD数量之间也无关联。与我们的假设相反，在该孕妇样本中，我们未发现性激素与SRS、情绪或吸烟行为之间存在显著关联。试验注册ClinicalTrials.gov（NCT01811225），2012年12月6日。
