维生素K拮抗剂诱导的三种异常血浆蛋白的证实。

Demonstration of three anomalous plasma proteins induced by a vitamin K antagonist.

作者信息

Reekers P P, Lindhout M J, Kop-Klaassen B H, Hemker H C

机构信息

Laboratory for Cardiovascular and Blood Coagulation Biochemistry, Leiden University Medical Centre, Leiden, The Netherlands.

出版信息

Biochim Biophys Acta. 1973 Aug 30;317(2):559-62. doi: 10.1016/0005-2795(73)90252-3.

DOI:10.1016/0005-2795(73)90252-3

PMID:19999738

Abstract

With the aid of precipitating antibodies against the bovine coagulation factors II, IX, and X three immunologically non-identical proteins can be demonstrated that are induced by the administration of a vitamin K antagonist (phenprocoumon). Each of these proteins is immunologically identical to one of three coagulation factors mentioned. The proteins differ from normal coagulation factors (a) by a lack of biological activity; (b) by a faster anodic migration rate in the presence of Ca2+. The proteins appear in the plasma concomitantly with the decrease of the normal factor.

摘要

借助针对牛凝血因子II、IX和X的沉淀抗体，可以证明三种免疫上不同的蛋白质，它们是由维生素K拮抗剂（苯丙香豆素）的给药诱导产生的。这些蛋白质中的每一种在免疫上都与上述三种凝血因子之一相同。这些蛋白质与正常凝血因子的不同之处在于：（a）缺乏生物活性；（b）在Ca2+存在下阳极迁移速率更快。这些蛋白质在血浆中出现的同时，正常因子会减少。