牛凝血因子IX（克里斯马斯因子）与其他维生素K依赖血浆蛋白的氨基酸序列比较。
Comparison of amino acid sequence of bovine coagulation Factor IX (Christmas Factor) with that of other vitamin K-dependent plasma proteins.
作者信息
Katayama K, Ericsson L H, Enfield D L, Walsh K A, Neurath H, Davie E W, Titani K
出版信息
Proc Natl Acad Sci U S A. 1979 Oct;76(10):4990-4. doi: 10.1073/pnas.76.10.4990.
Abstract
The amino acid sequence of bovine blood coagulation Factor IX (Christmas Factor) is presented and compared with the sequences of other vitamin K-dependent plasma proteins and pancreatic trypsinogen. The 416-residue sequence of Factor IX was determined largely by automated Edman degradation of two large segments, containing 181 and 235 residues, isolated after activating Factor IX with a protease from Russell's viper venom. Subfragments of the two segments were produced by enzymatic digestion and by chemical cleavage of methionyl, tryptophyl, and asparaginyl-glycyl bonds. Comparison of the amino acid sequences of Factor IX, Factor X, and Protein C demonstrates that they are homologous throughout. Their homology with prothrombin, however, is restricted to the amino-terminal region, which is rich in gamma-carboxyglutamic acid, and the carboxyl-terminal region, which represents the catalytic domain of these proteins and corresponds to that of pancreatic serine proteases.
摘要
本文给出了牛凝血因子IX（克里斯马斯因子）的氨基酸序列，并将其与其他维生素K依赖的血浆蛋白及胰蛋白酶原的序列进行了比较。因子IX的416个残基序列主要通过对两个大片段进行自动埃德曼降解来确定，这两个大片段分别含有181个和235个残基，是在用罗素蝰蛇毒中的一种蛋白酶激活因子IX后分离得到的。通过酶切以及甲硫氨酰、色氨酰和天冬氨酰-甘氨酰键的化学裂解产生了这两个片段的亚片段。因子IX、因子X和蛋白C氨基酸序列的比较表明，它们在整体上具有同源性。然而，它们与凝血酶原的同源性仅限于富含γ-羧基谷氨酸的氨基末端区域以及代表这些蛋白质催化结构域且与胰丝氨酸蛋白酶催化结构域相对应的羧基末端区域。
相似文献
1
Comparison of amino acid sequence of bovine coagulation Factor IX (Christmas Factor) with that of other vitamin K-dependent plasma proteins.牛凝血因子IX（克里斯马斯因子）与其他维生素K依赖血浆蛋白的氨基酸序列比较。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):4990-4. doi: 10.1073/pnas.76.10.4990.
2
The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens.
Biochem Biophys Res Commun. 1983 Aug 30;115(1):8-14. doi: 10.1016/0006-291x(83)90961-0.
3
A comparison of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor).牛凝血酶原、因子IX（克里斯马斯因子）和因子X（斯图尔特因子）的比较。
Proc Natl Acad Sci U S A. 1974 Feb;71(2):427-30. doi: 10.1073/pnas.71.2.427.
4
Degradation of coagulation proteins by an enzyme from Malayan pit viper (Akistrodon rhodostoma) venom.
Biochemistry. 1987 Dec 1;26(24):7627-36. doi: 10.1021/bi00398a015.
5
Bovine factor IX (Christmas factor). Further evidence of homology with factor X (Stuart factor) and prothrombin.牛凝血因子IX（克里斯马斯因子）。与凝血因子X（斯图尔特因子）和凝血酶原同源性的进一步证据。
FEBS Lett. 1974 Oct 1;47(1):132-5. doi: 10.1016/0014-5793(74)80442-4.
6
A method for systematic purification from bovine plasma of six vitamin K-dependent coagulation factors: prothrombin, factor X, factor IX, protein S, protein C, and protein Z.
J Biochem. 1985 May;97(5):1347-55. doi: 10.1093/oxfordjournals.jbchem.a135187.
7
A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S.人凝血酶原、因子IX（克里斯马斯因子）、因子X（斯图尔特因子）和蛋白S的比较。
Biochemistry. 1977 Feb 22;16(4):698-706. doi: 10.1021/bi00623a022.
8
Contributions of Gla and EGF-like domains to the function of vitamin K-dependent coagulation factors.γ-羧基谷氨酸（Gla）和表皮生长因子（EGF）样结构域对维生素K依赖性凝血因子功能的贡献。
Crit Rev Eukaryot Gene Expr. 1999;9(1):59-88.
9
The structural aspects of vitamin K-dependent blood coagulation factors.
Nihon Ketsueki Gakkai Zasshi. 1982 Jul;45(4):807-16.
10
Primary structure of bovine vitamin K-dependent protein S.牛维生素K依赖蛋白S的一级结构
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4199-203. doi: 10.1073/pnas.83.12.4199.
引用本文的文献
1
Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma.用于在人血浆中成像和抑制因子 XIa 活性的荧光活性探针。
J Med Chem. 2023 Mar 23;66(6):3785-3797. doi: 10.1021/acs.jmedchem.2c00845. Epub 2023 Mar 10.
2
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product.生物反应器细胞培养上清液中的凝血因子 IX 分析可预测纯化产物的质量。
Commun Biol. 2021 Mar 23;4(1):390. doi: 10.1038/s42003-021-01903-x.
3
A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry.采用纳米盘氢交换质谱法研究前肽与整合膜蛋白 γ-谷氨酰羧化酶的结合构象。
Biochemistry. 2014 Mar 11;53(9):1511-20. doi: 10.1021/bi401536m. Epub 2014 Feb 26.
4
Post-translational carboxylation of preprothrombin.凝血酶原前体的翻译后羧化作用。
Mol Cell Biochem. 1981 Aug 11;38 Spec No(Pt 1):77-121. doi: 10.1007/BF00235690.
5
Characterization of the defect in activation of factor IX Chapel Hill by human factor XIa.人因子XIa对因子IX Chapel Hill激活缺陷的特征分析。
J Clin Invest. 1981 Dec;68(6):1420-6. doi: 10.1172/jci110393.
6
Isolation and characterization of a cDNA coding for human factor IX.编码人凝血因子IX的cDNA的分离与鉴定
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6461-4. doi: 10.1073/pnas.79.21.6461.
7
Isolation of a human anti-haemophilic factor IX cDNA clone using a unique 52-base synthetic oligonucleotide probe deduced from the amino acid sequence of bovine factor IX.利用从牛凝血因子IX氨基酸序列推导出来的一段独特的52个碱基的合成寡核苷酸探针分离人抗血友病因子IX cDNA克隆。
Nucleic Acids Res. 1983 Apr 25;11(8):2325-35. doi: 10.1093/nar/11.8.2325.
8
Identification of the molecular defect in factor IX Chapel Hill: substitution of histidine for arginine at position 145.凝血因子IX查珀尔希尔分子缺陷的鉴定：第145位精氨酸被组氨酸取代。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4200-2. doi: 10.1073/pnas.80.14.4200.
9
beta-Hydroxyaspartic acid in vitamin K-dependent protein C.维生素K依赖蛋白C中的β-羟基天冬氨酸
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1802-6. doi: 10.1073/pnas.80.7.1802.
10
Gamma-carboxyglutamic acid.γ-羧基谷氨酸
Mol Cell Biochem. 1981 Sep 25;39:191-207. doi: 10.1007/BF00232574.
本文引用的文献
1
Plasma thromboplastin component (PTC) deficiency; a new disease resembling hemophilia.血浆凝血活酶成分（PTC）缺乏症；一种类似血友病的新疾病。
Proc Soc Exp Biol Med. 1952 Apr;79(4):692-4. doi: 10.3181/00379727-79-19488.
2
Christmas disease: a condition previously mistaken for haemophilia.克里斯马斯病：一种曾被误诊为血友病的病症。
Br Med J. 1952 Dec 27;2(4799):1378-82. doi: 10.1136/bmj.2.4799.1378.
3
A protein sequenator.蛋白质测序仪。
Eur J Biochem. 1967 Mar;1(1):80-91. doi: 10.1007/978-3-662-25813-2_14.
4
Solid-phase Edman degradation. An automatic peptide sequencer.固相埃德曼降解法。一种自动肽序列分析仪。
Eur J Biochem. 1971 May 11;20(1):89-102. doi: 10.1111/j.1432-1033.1971.tb01366.x.
5
Isolation and characterization of bovine factor IX (Christmas factor).牛凝血因子IX（克里斯马斯因子）的分离与特性鉴定。
Biochemistry. 1973 Nov 20;12(24):4938-45. doi: 10.1021/bi00748a019.
6
Application of sequenator analyses to the study of proteins.序列分析仪分析在蛋白质研究中的应用。
Biochemistry. 1972 Nov 21;11(24):4493-502. doi: 10.1021/bi00774a011.
7
Bovine factor X 1 (Stuart factor). Mechanism of activation by protein from Russell's viper venom.牛凝血因子X1（斯图尔特因子）。被锯鳞蝰蛇毒中的蛋白质激活的机制。
Biochemistry. 1972 Dec 19;11(26):4892-9. doi: 10.1021/bi00776a003.
8
Metabolism and properties of a liver precursor to prothrombin.凝血酶原肝脏前体的代谢与特性
Vitam Horm. 1974;32:463-81. doi: 10.1016/s0083-6729(08)60023-0.
9
Determination of the tryptophan content of proteins by ion exchange chromatography of alkaline hydrolysates.通过碱性水解产物的离子交换色谱法测定蛋白质中的色氨酸含量。
J Biol Chem. 1972 May 10;247(9):2828-34.
10
Bovine factor IX (Christmas factor). Further evidence of homology with factor X (Stuart factor) and prothrombin.牛凝血因子IX（克里斯马斯因子）。与凝血因子X（斯图尔特因子）和凝血酶原同源性的进一步证据。
FEBS Lett. 1974 Oct 1;47(1):132-5. doi: 10.1016/0014-5793(74)80442-4.
Zotero 插件