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[应激条件下作为生物抗氧化剂的抗惊厥药]

[Anticonvulsants as bioantioxidants under stress conditions].

作者信息

Bogdanov G N, Mishchenko D V, Kotel'nikova R A, Frog E S, Faĭngol'd I I, Tat'ianenko L V, Dorokhotova O V, Nartsissov Ia R

出版信息

Biomed Khim. 2009 Jul-Aug;55(4):519-24.

PMID:20000129
Abstract

The action of heterocyclic amides series (ethosuximide, phenytoin, primidone) on lipid peroxidation and membrane bound monoamine oxidases A and B under stress condition has been studied. The intraperitoneal injection of the drugs resulted in enhancement of SOD, decrease of brain malondialdehyde content and mitochondrial activity of monoamine oxidases A and B.

摘要

研究了杂环酰胺类(乙琥胺、苯妥英、扑米酮)在应激条件下对脂质过氧化以及膜结合单胺氧化酶A和B的作用。腹腔注射这些药物导致超氧化物歧化酶活性增强、脑丙二醛含量降低以及单胺氧化酶A和B的线粒体活性降低。

相似文献

1
[Anticonvulsants as bioantioxidants under stress conditions].[应激条件下作为生物抗氧化剂的抗惊厥药]
Biomed Khim. 2009 Jul-Aug;55(4):519-24.
2
[Effect of some anticonvulsants in vitro and in vivo on the activity of enzymes in rat brain].[某些抗惊厥药在体内外对大鼠脑内酶活性的影响]
Neurol Neurochir Pol. 1974 May-Jun;8(3):413-20.
3
[Protection of the monoamine oxidase in brain synaptosomes by fat- and water-soluble antioxidants during lipid peroxidation].
Biull Eksp Biol Med. 1989 Feb;107(2):169-71.
4
The influence of antiepileptic drugs on some enzymes activity in the brain of mice with audiogenic epilepsy. Note I. The action of phenobarbital, diphenylhydantoin and primidone.抗癫痫药物对听源性癫痫小鼠大脑中某些酶活性的影响。注释I. 苯巴比妥、苯妥英钠和扑米酮的作用。
Neurol Psychiatr (Bucur). 1976 Apr-Jun;14(2):119-28.
5
Genistein reduced the neural apoptosis in the brain of ovariectomised rats by modulating mitochondrial oxidative stress.染料木黄酮通过调节线粒体氧化应激减少去卵巢大鼠大脑中的神经细胞凋亡。
Br J Nutr. 2010 Nov;104(9):1297-303. doi: 10.1017/S0007114510002291. Epub 2010 Jun 28.
6
An in vitro approach to assess the neurotoxicity of valproic acid-induced oxidative stress in cerebellum and cerebral cortex of young rats.评估丙戊酸诱导的氧化应激对幼鼠小脑和大脑皮质神经毒性的体外研究方法。
Neuroscience. 2012 Dec 6;225:258-68. doi: 10.1016/j.neuroscience.2012.08.060. Epub 2012 Sep 6.
7
A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and primidone in mice.抗癫痫药物卡马西平、氯硝西泮、乙琥胺、苯巴比妥、苯妥英和扑米酮在小鼠体内致畸活性的比较。
Toxicol Appl Pharmacol. 1977 May;40(2):365-78. doi: 10.1016/0041-008x(77)90108-9.
8
Effect of MAO-B inhibition against ischemia-induced oxidative stress in the rat brain. Comparison with a rational antioxidant.单胺氧化酶B抑制对大鼠脑缺血诱导的氧化应激的影响。与合理抗氧化剂的比较。
Arzneimittelforschung. 2008;58(4):160-7. doi: 10.1055/s-0031-1296487.
9
Diazepam blocks striatal lipid peroxidation and improves stereotyped activity in a rat model of acute stress.地西泮阻断纹状体脂质过氧化作用,改善急性应激大鼠刻板行为。
Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):350-6. doi: 10.1111/j.1742-7843.2011.00738.x. Epub 2011 Jul 12.
10
[Rat brain lipid peroxidation system under conditions of emotional-pain stress of varying duration].[不同持续时间的情绪性疼痛应激条件下大鼠脑脂质过氧化系统]
Vopr Med Khim. 1993 Nov-Dec;39(6):28-31.

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