[Rat brain lipid peroxidation system under conditions of emotional-pain stress of varying duration].

Neurotization of rats, developed after long-term emotional-painful stress, resulted in activation of lipid peroxidation in brain both within 2 days and 8 days of stress interruption. Compensative activation of the antioxidative protective system in response to increase in lipid peroxidation rate was not observed especially in synaptosomes. Activation of glutathione peroxidase, which is involved in adaptation, was accompanied by inhibition of superoxide dismutase and glutathione transferase. Thus, the balance was impaired between the rate of lipid peroxidation and the mechanisms of antioxidative protection.