钯催化的串联胺化反应合成 4-喹诺酮。
Palladium-catalyzed tandem amination reaction for the synthesis of 4-quinolones.
机构信息
Department of Chemistry, Shanghai University, Shanghai 200444, China.
出版信息
Org Lett. 2010 Jan 15;12(2):212-5. doi: 10.1021/ol902626d.
PMID:20000580
Abstract
An efficient palladium-catalyzed tandem amination approach was developed in one step to afford functionalized 4-quinolones in good to excellent yields from easily accessible o-haloaryl acetylenic ketones and primary amines.
摘要
开发了一种高效的钯催化串联氨化方法，可从易得的邻卤芳基炔基乙酰酮和伯胺一步合成官能化的 4-喹诺酮，产率良好至优秀。
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