College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325035, China.
Org Lett. 2011 May 6;13(9):2184-7. doi: 10.1021/ol200404z. Epub 2011 Apr 7.
A new, simple method for selectively synthesizing alkyl aryl ketones has been developed by palladium-catalyzed oxidative coupling of trialkylamines with aryl iodides. In the presence of PdCl(2)(MeCN)(2), TBAB, and ZnO, a variety of aryl iodides underwent an oxidative coupling reaction with tertiary amines and water to afford the corresponding alkyl aryl ketones in moderate to excellent yields. It is noteworthy that this method is the first example of using trialkylamines as the carbonyl sources for constructing alkyl aryl ketone skeletons.
一种新的、简单的方法已经被开发出来，用于通过钯催化的三烷基胺与芳基碘化物的氧化偶联选择性合成烷基芳基酮。在 PdCl2(MeCN)2、TBAB 和 ZnO 的存在下，各种芳基碘化物与叔胺和水发生氧化偶联反应，以中等至优异的收率得到相应的烷基芳基酮。值得注意的是，这种方法是首次使用三烷基胺作为羰基源来构建烷基芳基酮骨架。
