Shitikov G S, Boldasov V K
Vopr Virusol. 1977 Jul-Aug(4):445-9.
A higher interfering activity of attenuated (vaccine) strains of parainfluenza virus types 1, 2 and 3 which had undergone a long-term adaptation to cell cultures as compared to the original viruses was established. The interferon-inducing activity of vaccine parainfluenza virus types 2 and 3 was also higher than that of the original viruses. The high interfering and interferon-inducing activity of attenuated parainfluenza virus strains of type 2 and 3 correlated with reduced virulence of these variants for man. These tests may be used for the assessment of virulence of parainfluenza virus strains type 2 and 3 in the laboratory.
已证实，与原始病毒相比，1型、2型和3型副流感病毒的减毒（疫苗）株在长期适应细胞培养后具有更高的干扰活性。2型和3型疫苗副流感病毒的干扰素诱导活性也高于原始病毒。2型和3型副流感病毒减毒株的高干扰和干扰素诱导活性与这些变体对人类的毒力降低相关。这些试验可用于实验室评估2型和3型副流感病毒株的毒力。
