NF-κB 激活途径：癌症预防和治疗的新兴分子靶点。
The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy.
机构信息
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.
出版信息
Expert Opin Ther Targets. 2010 Jan;14(1):45-55. doi: 10.1517/14728220903431069.
IMPORTANCE OF THE FIELD
Nuclear factor kappa B (NF-kappaB) is activated by a variety of cancer-promoting agents. The reciprocal activation between NF-kappaB and inflammatory cytokines makes NF-kappaB important for inflammation-associated cancer development. Both the constitutive and anticancer therapeutic-induced NF-kappaB activation blunts the anticancer activities of the therapy. Elucidating the roles of NF-kappaB in cancer facilitates developing approaches for cancer prevention and therapy.
AREAS COVERED IN THIS REVIEW
By searching PubMed, we summarize the progress of studies on NF-kappaB in carcinogenesis and cancer cells' drug resistance in recent 10 years.
WHAT THE READER WILL GAIN
The mechanisms by which NF-kappaB activation pathways are activated; the roles and mechanisms of NF-kappaB in cell survival and proliferation, and in carcinogenesis and cancer cells' response to therapy; recent development of NF-kappaB-modulating means and their application in cancer prevention and therapy.
TAKE HOME MESSAGE
NF-kappaB is involved in cancer development, modulating NF-kappaB activation pathways has important implications in cancer prevention and therapy. Due to the complexity of NF-kappaB roles in different cancers, careful evaluation of NF-kappaB's in each cancer type is crucial in this regard. More cancer cell-specific NF-kappaB inhibiting means are desired for improving anticancer efficacy and reducing systemic toxicity.
重要性领域
核因子 kappa B（NF-κB）可被多种促进癌症的因子激活。NF-κB 与炎症细胞因子之间的相互激活使 NF-κB 成为与炎症相关的癌症发展的重要因素。NF-κB 的组成性激活和抗癌治疗诱导的激活均会削弱治疗的抗癌活性。阐明 NF-κB 在癌症中的作用有助于开发癌症预防和治疗方法。
本综述涵盖的领域
通过在 PubMed 上进行搜索，我们总结了近 10 年来 NF-κB 在致癌作用和癌细胞耐药性方面的研究进展。
读者将获得的收益
NF-κB 激活途径被激活的机制；NF-κB 在细胞存活和增殖、致癌作用以及癌细胞对治疗的反应中的作用和机制；NF-κB 调节手段的最新发展及其在癌症预防和治疗中的应用。
重要信息
NF-κB 参与癌症的发生发展，调节 NF-κB 激活途径对癌症的预防和治疗具有重要意义。由于 NF-κB 在不同癌症中的作用复杂，因此在这方面仔细评估 NF-κB 在每种癌症类型中的作用至关重要。需要更多针对癌细胞特异性的 NF-κB 抑制手段，以提高抗癌疗效并降低全身毒性。
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