Lu Yuan-Gang, Wu Jin-Jin, He Yang, Yang Hong-Zhen, Yang Ya-Dong
Department of Dermatology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.
Photomed Laser Surg. 2010 Aug;28(4):561-3. doi: 10.1089/pho.2009.2566.
To evaluate the safety and efficacy of topical aminolevulinic acid (ALA) photodynamic therapy (PDT) in the treatment of verruca planae.
A total of 18 patients with facial verruca planae was treated with ALA-PDT. A 10% ALA emulsion was applied on facial lesions for a 4-h incubation period after azone infiltrating for 30 min. Skin lesions of verruca planae were irradiated with 120 J/cm(2) using a 635-nm laser for 10 min. Each patient received at least two sessions at intervals of 15 days. Those with residual lesions after the first session were treated with a third PDT. Before treatment and at each return visit, the lesions were photographed. Patient satisfaction was investigated and therapeutic effect was evaluated at 6 months after termination of the therapy.
Fifteen days after the first topical ALA-PDT, 10 patients achieved complete response and 7 patients showed improvement. Complete clinical response was observed in 17 patients after two sessions. At 6 months after termination, only one case relapsed among the complete clinical response patients, and the patient satisfaction rate was 88.89%.
PDT, utilizing the topical application of 10% ALA, has a good result and excellent cosmetic effects for the treatment of verruca planae.
评估外用氨基酮戊酸（ALA）光动力疗法（PDT）治疗扁平疣的安全性和有效性。
共有18例面部扁平疣患者接受ALA-PDT治疗。在使用氮酮浸润30分钟后，将10%的ALA乳剂涂抹于面部皮损上，孵育4小时。使用635纳米激光以120焦每平方厘米的能量对面部扁平疣皮损照射10分钟。每位患者至少接受两次治疗，间隔15天。首次治疗后有残留皮损的患者接受第三次PDT治疗。在治疗前及每次复诊时，对皮损进行拍照。在治疗结束6个月时调查患者满意度并评估治疗效果。
首次外用ALA-PDT治疗15天后，10例患者达到完全缓解，7例患者有改善。两次治疗后17例患者出现完全临床缓解。在治疗结束6个月时，完全临床缓解的患者中仅1例复发，患者满意度为88.89%。
使用10%ALA外用的PDT治疗扁平疣效果良好，美容效果极佳。
