Department of Medical Science and Cardiorenal Medicine, Yokoham City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama City, Japan.
Clin Exp Hypertens. 2009 Nov;31(8):680-9. doi: 10.3109/10641960903407041.
The aim of the present study was to examine the relationships between the anti-hypertensive effects, autonomic function, and health-related quality of life (HRQOL) following treatment of hypertensive subjects with angiotensin receptor blockers (ARBs) in hypertensives. Nineteen patients with hypertension were assigned randomly to daily treatment with ARBs. After 16 weeks of treatment, blood pressure (BP) and 24 h the ratio of low frequency to high frequency component (LF/HF), an index of sympathovagal balance were decreased by ARBs. The HRQOL scores improved during the study. In this study, ARB therapy was associated with an improvement in BP, autonomic function, and HRQOL.
本研究旨在探讨高血压患者接受血管紧张素受体阻滞剂（ARBs）治疗后，降压效果、自主神经功能与健康相关生活质量（HRQOL）之间的关系。19 例高血压患者被随机分为每日接受 ARBs 治疗。治疗 16 周后，ARBs 降低了血压（BP）和 24 小时低频与高频成分的比值（LF/HF），即交感神经与副交感神经平衡的指标。研究过程中 HRQOL 评分有所改善。在本研究中，ARB 治疗与血压、自主神经功能和 HRQOL 的改善有关。
