Division of Infectious Diseases, Georgetown University, Washington, DC 20007, USA.
Expert Opin Drug Metab Toxicol. 2010 Jan;6(1):105-14. doi: 10.1517/17425250903490418.
Lamivudine is a nucleoside reverse transcriptase inhibitor that is widely used for the treatment of HIV-1 infection in combination with other antiretrovirals. It is a highly effective agent that can be dosed once or twice daily due to its long intracellular half-life. It also has one of the best tolerability and long-term safety profiles among all antiretroviral agents and continues to be preferred as part of initial or subsequent combination therapy in HIV-infected patients.
拉米夫定是一种核苷类逆转录酶抑制剂，广泛用于与其他抗逆转录病毒药物联合治疗 HIV-1 感染。由于其较长的细胞内半衰期，它是一种非常有效的药物，可以每日一次或两次给药。它也是所有抗逆转录病毒药物中耐受性和长期安全性最好的药物之一，并且仍然是 HIV 感染患者初始或后续联合治疗的首选药物之一。
