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慢性创伤后骨髓炎患者的功能预后

Functional outcome in patients treated for chronic posttraumatic osteomyelitis.

作者信息

Egol Kenneth A, Singh Jaspal R, Nwosu Uzoma

机构信息

Division of Orthopaedic Trauma, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, New York, USA.

出版信息

Bull NYU Hosp Jt Dis. 2009;67(4):313-7.

Abstract

BACKGROUND

Management of chronic posttraumatic osteomyelitis remains an important challenge in orthopaedics. In this investigation, 43 patients at a large university hospital were retrospectively identified who had been diagnosed with chronic osteomyelitis at 44 sites.

METHODS

Diagnosis was based on the patient's history and physical examination, laboratory values, radiological evaluation, and intraoperative specimens. Patients' charts were reviewed and follow-up was obtained on 33 patients in whom Short Musculoskeletal Functional Assessment (SMFA) questionnaires were obtained.

RESULTS

The mean follow-up of the cohort was 21.1 months (range, 10 to 54 months). Sites involved included: tibia (55%) and femur (36%), with the remainder involving the pelvis, radius/ulna, and calcaneus. Blood, bone, or wound aspirate cultures were positive in 85%, most commonly for Staphylococcus aureus. 84% of the patients in this investigation were completely cured after a single surgical intervention, removal of hardware and a course of intravenous antibiotics. Three patients required additional surgical intervention and two remained infected. Ultimately, the cohort reached a cure rate of 94%. SMFA data revealed that patients had a dysfunction score of 53.8 and bother index of 51.5, with 50 being the normal for the general population.

CONCLUSION

The patients in this cohort functioned at a level less than one standard deviation below the general population. These results suggest that patients with chronic posttraumatic osteomyelitis do not function significantly below that of the normal population following eradication of their infections.

摘要

背景

慢性创伤后骨髓炎的治疗仍是骨科领域的一项重大挑战。在本研究中,我们对一家大型大学医院的43例患者进行了回顾性分析,这些患者在44个部位被诊断为慢性骨髓炎。

方法

诊断基于患者的病史、体格检查、实验室检查结果、影像学评估以及术中标本。我们查阅了患者的病历,并对33例患者进行了随访,这些患者均填写了简短肌肉骨骼功能评估(SMFA)问卷。

结果

该队列的平均随访时间为21.1个月(范围为10至54个月)。受累部位包括:胫骨(55%)和股骨(36%),其余部位包括骨盆、桡骨/尺骨和跟骨。血液、骨骼或伤口穿刺培养阳性率为85%,最常见的病原菌是金黄色葡萄球菌。本研究中84%的患者在接受一次手术干预、取出内固定物并进行一个疗程的静脉抗生素治疗后完全治愈。3例患者需要额外的手术干预,2例仍有感染。最终,该队列的治愈率达到94%。SMFA数据显示,患者的功能障碍评分为53.8,困扰指数为51.5,而一般人群的正常范围为50。

结论

该队列患者的功能水平比一般人群低不到一个标准差。这些结果表明,慢性创伤后骨髓炎患者在感染根除后,其功能水平与正常人群相比并无显著下降。

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