2 型糖尿病患者的利手性、胰岛素敏感性和胰岛 B 细胞功能。

Handedness, insulin sensitivity and pancreatic B-cell function in Type 2 diabetes.

机构信息

Department of Endocrinology and Nutrition, Université catholique de Louvain, Brussels, Belgium.

出版信息

Diabet Med. 2009 Dec;26(12):1289-92. doi: 10.1111/j.1464-5491.2009.02826.x.

DOI:10.1111/j.1464-5491.2009.02826.x

PMID:20002483

Abstract

BACKGROUND

Laterality is associated with various health conditions. No study has addressed the influence of handedness on Type 2 diabetes mellitus (T2DM) phenotype, including glucose homeostasis, glucose-lowering therapies and metabolic control.

METHODS

Five hundred and seventy-six consecutive adult T2DM outpatients underwent homeostasis model assessment (HOMA) of pancreatic B-cell function (B), insulin sensitivity (S), hyperbolic product (B x S) and age-standardized B x S deficit. Right-handed patients (87.5%; RH; n = 504) had similar age, gender, diabetes duration and education than non-right-handed patients (12.5%; non-RH; n = 72).

RESULTS

Non-RH were more insulin-sensitive: 66% (39%) vs. 52% (36%) [mean (1 sd); P = 0.0024] and had significantly higher B x S and lower age-adjusted B x S deficit: 35% (20%) vs. 26% (17%) and 1.08% (0.40%) vs. 1.32% (0.55%)/year (non-RH; P = 0.0005 and P < 0.0001, respectively).

CONCLUSIONS

Non-right-handed T2DM patients are more insulin-sensitive, have higher hyperbolic product and less age-standardized B x S deficit. These may modulate glucose-lowering therapy requirements and glycaemic control.

摘要

背景

偏侧性与各种健康状况有关。目前尚无研究探讨利手性对 2 型糖尿病（T2DM）表型的影响，包括葡萄糖稳态、降糖治疗和代谢控制。

方法

576 例连续成年 T2DM 门诊患者进行了胰岛 B 细胞功能（B）、胰岛素敏感性（S）、双曲线乘积（B×S）和年龄标准化 B×S 缺陷的稳态模型评估（HOMA）。右利手患者（87.5%；RH；n=504）的年龄、性别、糖尿病病程和教育程度与非右利手患者（12.5%；非 RH；n=72）相似。

结果

非 RH 患者胰岛素敏感性更高：66%（39%）比 52%（36%）[平均值（1 sd）；P=0.0024]，B×S 更高，年龄校正 B×S 缺陷更低：35%（20%）比 26%（17%）和 1.08%（0.40%）比 1.32%（0.55%）/年（非 RH；P=0.0005 和 P<0.0001）。