Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
J Oral Pathol Med. 2010 Feb;39(2):195-200. doi: 10.1111/j.1600-0714.2009.00839.x. Epub 2009 Dec 7.
The aim of this study was to determine if route of human immunodeficiency virus (HIV) transmission is associated with the risk of oral lesions in HIV-infected subjects in Thailand.
A cross-sectional study was performed in 186 HIV-infected heterosexuals (aged 21-65 years, mean 32 years), and 82 HIV-infected intravenous drug users (IVDUs) (aged 16-50 years, mean 30 years). The following information was recorded: route of HIV transmission, total lymphocyte cell counts, weight, smoking habit, alcohol consumption, medications, presence of denture, plaque index, and presence of oral lesions. The association between mode of HIV transmission and the risk of oral lesions among the subjects was determined by multiple logistic regression analysis.
Oral lesions were found in 138 HIV-infected heterosexuals (75%) and in 37 HIV-infected IVDUs (46%). Oral candidiasis (OC) was the most common lesion among both groups (44% vs. 28%), followed by hairy leukoplakia (HL) (33% vs. 10%). Multiple logistic regression analysis showed a significant association between mode of HIV transmission and the risk of oral lesions after controlling for the total lymphocyte cell counts and other confounding factors [OR 3.1; 95% CI 1.5-6.4; P = 0.002]. OC was significantly associated with heterosexual route of HIV transmission [OR 2.4; 95% CI 1.2-4.7; P = 0.014]. Similar association was also observed with HL [OR 3.7; 95% CI 1.5-9.1; P = 0.004].
Mode of HIV transmission is associated with the risk of oral lesions in HIV-infected subjects in Thailand. Further studies should be performed to determine if the risk of oral lesions is associated with differences in HIV-subtypes.
本研究旨在确定人类免疫缺陷病毒（HIV）传播途径是否与泰国 HIV 感染者发生口腔病变的风险相关。
在 186 名 HIV 感染的异性恋者（年龄 21-65 岁，平均 32 岁）和 82 名 HIV 感染的静脉吸毒者（IVDUs）（年龄 16-50 岁，平均 30 岁）中进行了一项横断面研究。记录了以下信息：HIV 传播途径、总淋巴细胞计数、体重、吸烟习惯、饮酒习惯、药物使用、义齿、菌斑指数和口腔病变。通过多变量逻辑回归分析确定了 HIV 传播方式与受试者口腔病变风险之间的关联。
在 138 名 HIV 感染的异性恋者（75%）和 37 名 HIV 感染的 IVDUs（46%）中发现了口腔病变。两组中最常见的病变是口腔念珠菌病（OC）（44%比 28%），其次是毛状白斑（HL）（33%比 10%）。多变量逻辑回归分析显示，在校正总淋巴细胞计数和其他混杂因素后，HIV 传播方式与口腔病变的风险之间存在显著关联[比值比 3.1；95%置信区间 1.5-6.4；P = 0.002]。OC 与 HIV 经异性传播途径显著相关[比值比 2.4；95%置信区间 1.2-4.7；P = 0.014]。HL 也观察到类似的关联[比值比 3.7；95%置信区间 1.5-9.1；P = 0.004]。
HIV 传播方式与泰国 HIV 感染者口腔病变的风险相关。应进一步研究以确定口腔病变的风险是否与 HIV 亚型的差异相关。
