Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY 10032, USA.
Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 1):260-7. doi: 10.1111/j.1399-3038.2009.00980.x. Epub 2009 Dec 9.
Exposure to polycyclic aromatic hydrocarbons (PAH) has been associated with allergic sensitization and asthma. We hypothesized that increased urinary PAH metabolites are associated with allergy or asthma among children age 5 yrs in an inner-city birth cohort. As part of an ongoing prospective birth cohort under the auspices of the Columbia Center for Children's Environmental Health (CCCEH), urine was collected from 5-yr-old children (n = 222) of Dominican American and African American mothers in Northern Manhattan and South Bronx of New York City. Twenty-four PAH metabolites were measured in these specimens, and their levels (unadjusted and specific gravity corrected) were evaluated with IgE levels and asthma outcomes. Ten metabolites were detected in urine from all children. Concentrations ranged higher than those in representative samples of US children ages 6-11 in the National Health and Nutrition Examination Survey (NHANES). Among CCCEH children, compared with African Americans, the Dominican children had higher 2-hydroxynaphthalene but lower 9-hydroxyfluorene and 4-hydroxyphenanthrene concentrations. Increased 3-hydroxyfluorene and 3-hydroxyphenanthrene levels were associated with higher anti-mouse IgE levels (p < 0.05). These plus 2-hydroxynaphthalene, 2-hydroxyflourene and 1-hydroxyphenanthrene concentrations were associated with higher anti-mouse IgE levels on multivariate analyzes. Increased 2-hydroxyphenanthrene, 3-hydroxyphenanthrene and 4-hydroxyphenanthrene levels were associated with higher anti-cat IgE levels (p < 0.05) in univariate, but not multivariate, analyzes. Levels of PAH metabolites were not associated with respiratory symptoms. Measures of PAH metabolites suggest considerable exposure in an urban pediatric population, and possible associations with allergic sensitization to mouse.
多环芳烃 (PAH) 的暴露与过敏致敏和哮喘有关。我们假设，在一个城市出生队列中，5 岁儿童尿液中多环芳烃代谢物增加与过敏或哮喘有关。作为哥伦比亚儿童环境健康中心 (CCCEH) 正在进行的前瞻性出生队列的一部分，从居住在纽约市北部曼哈顿和南布朗克斯的多米尼加裔美国人和非裔美国母亲的 5 岁儿童 (n = 222) 中收集尿液。在这些标本中测量了 24 种多环芳烃代谢物，并用 IgE 水平和哮喘结果评估了它们的水平（未经调整和比重校正）。所有儿童的尿液中均检测到 10 种代谢物。浓度范围高于国家健康和营养检查调查 (NHANES) 中美国 6-11 岁儿童的代表性样本。在 CCCEH 儿童中，与非裔美国人相比，多米尼加儿童的 2-羟基萘酚浓度较高，但 9-羟基芴和 4-羟基菲酚浓度较低。3-羟基芴和 3-羟基菲酚水平升高与抗鼠 IgE 水平升高相关（p < 0.05）。这些加上 2-羟基萘酚、2-羟基芴和 1-羟基菲酚浓度与多元分析中更高的抗鼠 IgE 水平相关。在单变量分析中，2-羟基菲酚、3-羟基菲酚和 4-羟基菲酚水平升高与更高的抗猫 IgE 水平相关（p < 0.05），但在多元分析中则不然。多环芳烃代谢物水平与呼吸道症状无关。多环芳烃代谢物的测量表明，在城市儿科人群中存在相当大的暴露，并且可能与对老鼠的过敏致敏有关。
