Jo Jeong Hun, Kim Dae Hwan, Ryu Ji Young
Department of Occupational and Environmental Medicine, Inje University Haeundae Paik Hospital, Busan, Korea.
Ann Occup Environ Med. 2022 Dec 14;34:e43. doi: 10.35371/aoem.2022.34.e43. eCollection 2022.
Polycyclic aromatic hydrocarbons (PAHs) have become common pollutants with industrial development. Although the effect of exposure to PAHs on allergic disease in humans has been evaluated, evidence of an association is sparse. The association between PAH exposure and serum total immunoglobulin E (IgE) levels was evaluated in Korean adults.
In total, this study included 3,269 participants in the Third Korean National Environmental Health Survey (2015-2017). Four urinary PAH metabolites were used to assessed exposure to PAHs: 1-hydroxypyrene, 1-hydroxyphenanthrene, 2-naphthol, and 2-hydroxyfluorene. The analyses were performed on 3 cutoff levels (100 IU/mL, 114 IU/mL, and 150 IU/mL) set as the total IgE elevation. Prevalence of total IgE elevation by PAH exposure group and general characteristics (age, sex, BMI, smoking, alcohol drinking, and occupation) were analyzed using the Rao-Scott χ test. Multiple logistic regression analyses were conducted to calculate adjusted odds ratios (ORs) for total IgE elevation by PAH exposure groups.
Total IgE elevation differed significantly by age, sex, smoking status, alcohol drinking status, and occupation. For 2-hydroxyfluorene, the fourth quartile showed a significant association with IgE elevation compared to the first quartile in the analyses of cutoff-level 100 IU/mL (OR: 1.372, 95% confidence interval [CI]: 1.007-1.869) and 114 IU/mL (OR: 1.643, 95% CI: 1.167-2.312). In the analysis of cutoff-level 150 IU/mL, the adjusted ORs of the third and fourth quartile of 2-hydroxyfluorene were significantly higher than the first quartile (3rd quartile: OR: 1.478, 95% CI: 1.034-2.113; 4th quartile: OR: 1.715, 95% CI: 1.161-2.534). However, there were no significant positive associations for the other metabolites.
This study implied that PAHs exposure is associated with total IgE elevation in Korean adults. More research is needed to confirm the effect of exposure to PAHs on serum IgE and allergic diseases.
随着工业发展，多环芳烃（PAHs）已成为常见污染物。尽管已评估了人类接触PAHs对过敏性疾病的影响，但相关关联证据稀少。本研究评估了韩国成年人中PAH暴露与血清总免疫球蛋白E（IgE）水平之间的关联。
本研究总共纳入了韩国第三次全国环境卫生调查（2015 - 2017年）中的3269名参与者。使用四种尿中PAH代谢物评估PAHs暴露情况：1-羟基芘、1-羟基菲、2-萘酚和2-羟基芴。分析在设定为总IgE升高的三个临界值水平（100 IU/mL、114 IU/mL和150 IU/mL）上进行。使用Rao-Scott χ检验分析PAH暴露组总IgE升高的患病率以及一般特征（年龄、性别、体重指数、吸烟、饮酒和职业）。进行多因素逻辑回归分析以计算PAH暴露组总IgE升高的调整优势比（OR）。
总IgE升高在年龄、性别、吸烟状况、饮酒状况和职业方面存在显著差异。对于2-羟基芴，在临界值水平为100 IU/mL（OR：1.372，95%置信区间[CI]：1.007 - 1.869）和114 IU/mL（OR：1.643，95% CI：1.167 - 2.312）的分析中，与第一四分位数相比，第四四分位数显示出与IgE升高有显著关联。在临界值水平为150 IU/mL的分析中，2-羟基芴第三和第四四分位数的调整OR显著高于第一四分位数（第三四分位数：OR：1.478，95% CI：1.034 - 2.113；第四四分位数：OR：1.715，95% CI：1.161 - 2.534）。然而，其他代谢物未发现显著的正相关。
本研究表明韩国成年人中PAHs暴露与总IgE升高有关。需要更多研究来证实PAHs暴露对血清IgE和过敏性疾病的影响。
