中国汉族人群中 HLA-DRB1*15 和 DRB1*09 与麻风病的关联证据及 DRB1*09 对发病的影响。
Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population.
机构信息
Shandong Provincial Institute of Dermatovenereology, Jinan, Shandong Province, PR China.
出版信息
BMC Med Genet. 2009 Dec 11;10:133. doi: 10.1186/1471-2350-10-133.
Abstract
BACKGROUND
Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to Mycobacterium leprae. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population.
METHODS
The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals.
RESULTS
The HLA-DRB115 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB109 allele was lower among leprosy patients, especially those with early-onset disease.
CONCLUSION
HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.
摘要
背景
人类白细胞抗原 (HLA) 被认为可以调节对麻风分枝杆菌的免疫反应。HLA-DRB1 与麻风病的关联已在多个人群中得到报道，但尚未在中国人群中得到报道。
方法
采用聚合酶链反应-序列特异性寡核苷酸探针与 Luminex100（PCR-SSOP-Luminex）方法对 305 例麻风病患者和 527 名健康对照者的 HLA-DRB1 等位基因进行基因分型。
结果
麻风病患者 HLA-DRB115 等位基因的频率明显高于健康对照组，而 HLA-DRB109 等位基因的频率在麻风病患者中较低，尤其是在发病早的患者中。
结论
HLA-DRB1 等位基因与中国人群的麻风病易感性相关。HLA-DRB1*09 等位基因仅在发病早的麻风病患者亚组中具有保护作用。
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