Lu W-S, Zhang W-Y, Li Y, Wang Z-X, Zuo X-B, Cai L-Q, Zhu F, Wang J-F, Sun L-D, Zhang X-J, Yang S
Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.
Tissue Antigens. 2010 Oct;76(4):276-81. doi: 10.1111/j.1399-0039.2010.01509.x.
Keloids are common abnormal raised fibroproliferative lesions that can occur following even minor cutaneous trauma. There is strong evidence suggesting a genetic susceptibility in individuals affected by keloids including familial heritability, common occurrence in twins, and high prevalence in certain ethnic populations. Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to keloids. HLA class II molecules are critical to the development of CD4(+) T-lymphocyte responses through their role in antigen presentation. No report has been published on HLA-DRB1 association with keloids in Chinese Han individuals. To investigate the etiology of keloids, the polymerase chain reaction sequence-specific primer method was used to analyze the distribution of HLA-DRB1 alleles in 192 patients with keloids and 273 healthy control individuals. Controls were matched by sex, age, and race. The HLA-DRB115 allele [19.01% vs 12.09%, odds ratio(OR) = 2.10, Pc = 0.024] was significantly more prevalent among keloid patients than healthy controls, whereas the frequency of the HLA-DRB103 allele (1.04% vs 4.95%, OR = 0.19, Pc = 0.022) was lower among keloid patients. Furthermore, through stratified analysis, we found that the HLA-DRB1*15 allele is related to the multiple-site group, severe group, and family history of keloids. This study supports an association between HLA-DRB1 alleles and susceptibility or resistance to keloids in Chinese Han individuals. The association of certain HLA alleles with susceptibility or resistance to keloids provides clues to choosing proper preventive strategies against keloid disease.
瘢痕疙瘩是常见的异常增生性纤维增生性病变，即使是轻微的皮肤创伤后也可能发生。有强有力的证据表明，瘢痕疙瘩患者存在遗传易感性，包括家族遗传性、双胞胎中常见以及某些种族人群中的高患病率。有人提出人类白细胞抗原（HLA）可调节对瘢痕疙瘩的免疫反应。HLA II类分子通过其在抗原呈递中的作用，对CD4(+) T淋巴细胞反应的发展至关重要。关于中国汉族人群中HLA-DRB1与瘢痕疙瘩的关联尚未见报道。为了研究瘢痕疙瘩的病因，采用聚合酶链反应序列特异性引物法分析了192例瘢痕疙瘩患者和273例健康对照个体中HLA-DRB1等位基因的分布。对照组在性别、年龄和种族上进行了匹配。瘢痕疙瘩患者中HLA-DRB115等位基因[19.01%对12.09%，优势比（OR）=2.10，Pc = 0.024]的患病率显著高于健康对照组，而瘢痕疙瘩患者中HLA-DRB103等位基因的频率（1.04%对4.95%，OR = 0.19，Pc = 0.022）较低。此外，通过分层分析，我们发现HLA-DRB1*15等位基因与多部位组、严重组和瘢痕疙瘩家族史有关。本研究支持中国汉族个体中HLA-DRB1等位基因与瘢痕疙瘩易感性或抗性之间的关联。某些HLA等位基因与瘢痕疙瘩易感性或抗性的关联为选择针对瘢痕疙瘩疾病的适当预防策略提供了线索。
