Standard Process, Department of Research and Development, Palmyra, WI 53156, USA.
BMC Complement Altern Med. 2009 Dec 14;9:51. doi: 10.1186/1472-6882-9-51.
Congaplex and Immuplex are dietary supplements that have been traditionally used to support immune system function. The purpose of these experiments was to determine whether Congaplex and Immuplex affect immune function using primary and immortalized T lymphocytes.
Immortalized CEM and Jurkat T lymphocytes and primary peripheral mononuclear blood cells (PBMCs) were treated with the aqueous extracts from Congaplex and Immuplex to determine the effects of these products on cytokine production in activated T lymphocytes.
Congaplex enhanced phytohemagglutinin/phorbol 12-myristate 13-acetate (PHA/PMA) stimulation of both CEM and Jurkat cells as measured by the production of cytokines, while Immuplex suppressed PHA/PMA-induced production of cytokines, with the exception of interleukin (IL)-8 which was enhanced by Immuplex. In vitro treatment of PBMCs from 10 healthy donors with Congaplex or Immuplex decreased PHA-stimulated production of interferon (IFN)-gamma but increased the production of IL-13.
While the effects of Congaplex and Immuplex differed in these two models, these data demonstrate that the aqueous extracts from these two dietary supplements can affect the inflammatory response of T lymphocytes.
Congaplex 和 Immuplex 是两种膳食补充剂，传统上被用于支持免疫系统功能。这些实验的目的是确定 Congaplex 和 Immuplex 是否通过原代和永生化 T 淋巴细胞影响免疫功能。
用 Congaplex 和 Immuplex 的水提物处理永生化的 CEM 和 Jurkat T 淋巴细胞和原代外周血单核细胞（PBMC），以确定这些产品对活化 T 淋巴细胞细胞因子产生的影响。
Congaplex 增强了植物血凝素/佛波醇 12-肉豆蔻酸 13-醋酸酯（PHA/PMA）对 CEM 和 Jurkat 细胞的刺激作用，表现为细胞因子的产生增加，而 Immuplex 抑制了 PHA/PMA 诱导的细胞因子产生，除了白细胞介素（IL）-8 被 Immuplex 增强。用 Congaplex 或 Immuplex 体外处理来自 10 位健康供体的 PBMC，减少了 PHA 刺激的干扰素（IFN）-γ的产生，但增加了白细胞介素（IL）-13 的产生。
尽管 Congaplex 和 Immuplex 在这两种模型中的作用不同，但这些数据表明，这两种膳食补充剂的水提物可以影响 T 淋巴细胞的炎症反应。
