Carney A S, Evans A S, Mirza S, Psaltis A
Department of Otolaryngology - Head and Neck Surgery, Flinders Medical Centre and Flinders University, Adelaide, South Australia, Australia.
J Laryngol Otol. 2010 May;124(5):510-4. doi: 10.1017/S0022215109992398. Epub 2009 Dec 11.
A variety of treatment modalities are currently used to treat recurrent respiratory papillomatosis. We aimed to study the efficacy of radiofrequency cold ablation (coblation) for the treatment of laryngotracheal recurrent respiratory papillomatosis, by comparing treatment intervals for coblation and CO2 laser vaporisation.
Retrospective case series of adult patients with advanced laryngotracheal recurrent respiratory papillomatosis.
Six patients were treated for at least two years by CO2 laser vaporisation with or without intralesional cidofovir. All six subsequently underwent treatment with radiofrequency coblation with or without intralesional cidofovir. Coblation resulted in longer periods between interventions, compared with CO2 laser (p = 0.03).
Radiofrequency coblation appears to be an attractive alternative technique to CO2 laser for the surgical treatment of advanced laryngotracheal papillomata.
目前有多种治疗方式用于治疗复发性呼吸道乳头状瘤病。我们旨在通过比较射频冷消融（低温等离子消融）和二氧化碳激光汽化的治疗间隔，研究射频冷消融治疗喉气管复发性呼吸道乳头状瘤病的疗效。
对成年晚期喉气管复发性呼吸道乳头状瘤病患者进行回顾性病例系列研究。
6例患者接受了至少两年的二氧化碳激光汽化治疗，部分联合病灶内注射西多福韦。随后，所有6例患者均接受了射频冷消融治疗，部分联合病灶内注射西多福韦。与二氧化碳激光治疗相比，射频冷消融治疗后的干预间隔时间更长（p = 0.03）。
对于晚期喉气管乳头状瘤的手术治疗，射频冷消融似乎是一种比二氧化碳激光更具吸引力的替代技术。
