Leker Ronen R, Grigoriadis Savvas, Cohen José E
Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
Neurol Res. 2010 Oct;32(8):787-91. doi: 10.1179/174313209X382430.
Intra-arterial thrombolysis has been advocated for treatment of acute ischemic stroke and several prognostic factors were identified in these patients. Other endovascular methods aiming to recanalize occluded vessels including balloon angioplasty, stenting and use of mechanical clot retrieving devices were devised. To date, this approach is replaced by a multi-modal reperfusion therapy (MMRT) approach that emphasizes combination of various methods to achieve reperfusion. MMRT includes intra-arterial infusion of thrombolytics and/or antiplatelet agents, mechanical clot disruption and retrieval and balloon angioplasty with stent placement. Recent results suggest that MMRT results in higher chances for both recanalization of the occluded artery and reperfusion of the ischemic tissue.
动脉内溶栓已被提倡用于治疗急性缺血性卒中，并且在这些患者中确定了几个预后因素。还设计了其他旨在使闭塞血管再通的血管内方法，包括球囊血管成形术、支架置入术以及使用机械取栓装置。迄今为止，这种方法已被多模式再灌注治疗（MMRT）方法所取代，该方法强调结合各种方法以实现再灌注。MMRT包括动脉内输注溶栓剂和/或抗血小板药物、机械性血栓破碎和取出以及带支架置入的球囊血管成形术。最近的结果表明，MMRT使闭塞动脉再通和缺血组织再灌注的机会更高。
