Division of TB Control, British Columbia Centre for Disease Control and Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Int J Tuberc Lung Dis. 2010 Jan;14(1):106-12.
British Columbia (BC), Canada.
To determine the risk factors for pulmonary colonization by non-tuberculous mycobacteria (NTM).
Retrospective study of subjects colonized by NTM from 1990 to 2006. Subjects without mycobacterial disease and with at least three negative cultures served as controls.
Mycobacterium avium complex (MAC) species were the most common NTM. Risk factors of colonization included age > or = 60 years (aOR 2.3), female sex (aOR 1.2), residency in Canada for at least 10 years (aOR 3.8), Canadian-born aboriginal (aOR 1.8), and Canadian-born non-aboriginal (aOR 1.4). Predictors of MAC colonization included White race (aOR 1.6) and residency in Canada for at least 10 years, which was the strongest predictor (aOR 6.7). Aboriginal origin was associated with non-MAC colonization (aOR 1.8), and Canadian-born people from the East/South-East Asian ethnic groups were protected from MAC colonization (aOR 0.2), all aOR P < 0.05.
Older age, female sex, having been born in Canada, long residency in BC and White race predict pulmonary NTM colonization, while Aboriginal origin predicts non-MAC colonization. Further research is needed to identify environmental NTM sources in BC and to determine their relation to colonization and disease.
加拿大不列颠哥伦比亚省（BC）。
确定非结核分枝杆菌（NTM）肺部定植的危险因素。
对 1990 年至 2006 年间肺部被 NTM 定植的患者进行回顾性研究。选择无分枝杆菌病且至少进行了 3 次阴性培养的患者作为对照。
鸟分枝杆菌复合群（MAC）是最常见的 NTM。定植的危险因素包括年龄≥60 岁（比值比 2.3）、女性（比值比 1.2）、在加拿大居住至少 10 年（比值比 3.8）、加拿大出生的原住民（比值比 1.8）和加拿大出生的非原住民（比值比 1.4）。MAC 定植的预测因素包括白种人（比值比 1.6）和在加拿大居住至少 10 年，这是最强的预测因素（比值比 6.7）。原住民与非 MAC 定植有关（比值比 1.8），而来自东亚/东南亚族裔的加拿大出生者则可预防 MAC 定植（比值比 0.2），所有比值比 P 值均＜0.05。
年龄较大、女性、在加拿大出生、在 BC 长期居住和白种人预测肺部 NTM 定植，而原住民起源则预测非 MAC 定植。需要进一步研究以确定 BC 地区环境 NTM 来源及其与定植和疾病的关系。
