Hansen Ditte, Brandi Lisbet, Rasmussen Knud
Medicinsk Afdeling, Roskilde Sygehus, DK-4000, Roskilde, Denmark.
Ugeskr Laeger. 2009 Dec 7;171(50):3684-9.
Chronic kidney disease is associated with an increased risk of cardiovascular disease. Vitamin D deficiency is common in patients with chronic kidney disease. In epidemiological studies, vitamin D deficiency and absence of treatment with vitamin D is associated with increased cardiovascular mortality. Several possible mechanisms may explain how vitamin D can influence the development of cardiovascular disease. Clinical intervention studies are needed to clarify whether treatment with vitamin D decreases the risk of cardiovascular disease in chronic kidney disease.
慢性肾脏病与心血管疾病风险增加相关。维生素D缺乏在慢性肾脏病患者中很常见。在流行病学研究中，维生素D缺乏以及未接受维生素D治疗与心血管疾病死亡率增加有关。几种可能的机制可以解释维生素D如何影响心血管疾病的发展。需要进行临床干预研究来阐明维生素D治疗是否能降低慢性肾脏病患者发生心血管疾病的风险。
