Lee Wooseung, Kang Peter M
Beth Israel Deaconess Medical Center, Cardiovascular Division, 3 Blackfan Circle, Room 910, Boston, MA 02215, USA.
Curr Opin Investig Drugs. 2010 Mar;11(3):309-14.
Accumulating evidence suggests that vitamin D deficiency is associated with cardiovascular disease, and that vitamin D therapy may have significant mortality and morbidity benefits in the treatment of congestive heart failure. However, the potential protective role of vitamin D in the heart, as well as the mechanism of action of the hormone in this organ, are poorly understood. In this review, the potential mechanisms of action of vitamin D in cardiac dysfunction are discussed, and the experimental and clinical findings that provide evidence for a role of vitamin D in the treatment of cardiovascular diseases are reviewed.Accumulating evidence suggests that vitamin D deficiency is associated with cardiovascular disease, and that vitamin D therapy may have significant mortality and morbidity benefits in the treatment of congestive heart failure. However, the potential protective role of vitamin D in the heart, as well as the mechanism of action of the hormone in this organ, are poorly understood. In this review, the potential mechanisms of action of vitamin D in cardiac dysfunction are discussed, and the experimental and clinical findings that provide evidence for a role of vitamin D in the treatment of cardiovascular diseases are reviewed.
越来越多的证据表明，维生素D缺乏与心血管疾病有关，并且维生素D疗法在治疗充血性心力衰竭方面可能对降低死亡率和发病率有显著益处。然而，维生素D在心脏中的潜在保护作用以及该激素在这个器官中的作用机制，目前还知之甚少。在这篇综述中，我们讨论了维生素D在心脏功能障碍中的潜在作用机制，并回顾了为维生素D在治疗心血管疾病中发挥作用提供证据的实验和临床研究结果。越来越多的证据表明，维生素D缺乏与心血管疾病有关，并且维生素D疗法在治疗充血性心力衰竭方面可能对降低死亡率和发病率有显著益处。然而，维生素D在心脏中的潜在保护作用以及该激素在这个器官中的作用机制，目前还知之甚少。在这篇综述中，我们讨论了维生素D在心脏功能障碍中的潜在作用机制，并回顾了为维生素D在治疗心血管疾病中发挥作用提供证据的实验和临床研究结果。
