Department of Neurology, The Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia.
J Clin Neurosci. 2010 Jan;17(1):29-33. doi: 10.1016/j.jocn.2009.04.010. Epub 2009 Dec 9.
This study sought to define the growth of unruptured intracranial aneurysms, in particular the frequency of growth and the characteristic factors predictive of growth. Two hundred and eight patients with 285 unruptured aneurysms were followed. Electronic records and angiographic films were obtained for measurements of aneurysm size. The mean follow-up duration was 21.8 months (range 1.1-137.3 months). Growth was identified in 95 of the 285 aneurysms (33.3%). The cumulative incidence of growth predicted using the Kaplan-Meier method was 22.7% at 1 year, 35.2% at 2 years, and 47.7% at 3 years. Aneurysm growth was significantly associated with a patient history of excessive alcohol consumption (p=0.04). A high incidence of growth can be seen in conservatively managed aneurysms with time. Consequently, continual follow-up is recommended to monitor for aneurysmal growth.
本研究旨在定义未破裂颅内动脉瘤的生长情况，特别是生长的频率和预测生长的特征因素。对 208 例 285 个未破裂动脉瘤患者进行了随访。获取电子病历和血管造影片以测量动脉瘤大小。平均随访时间为 21.8 个月（范围 1.1-137.3 个月）。在 285 个动脉瘤中发现 95 个（33.3%）发生了生长。使用 Kaplan-Meier 方法预测的生长累积发生率为：1 年时为 22.7%，2 年时为 35.2%，3 年时为 47.7%。动脉瘤生长与患者过量饮酒史显著相关（p=0.04）。随着时间的推移，保守治疗的动脉瘤中可见高发生率的生长。因此，建议持续随访以监测动脉瘤的生长情况。
