识别免疫球蛋白结构域在免疫功能中的其他作用。
Recognition of additional roles for immunoglobulin domains in immune function.
机构信息
University of South Florida, Department of Pediatrics, USF/ACH Children's Research Institute, 140 Seventh Avenue South, St. Petersburg, FL 33701, USA.
出版信息
Semin Immunol. 2010 Feb;22(1):17-24. doi: 10.1016/j.smim.2009.11.006. Epub 2009 Dec 8.
Abstract
Characterization of immune receptors found in phylogenetically disparate species at the genetic, structural and functional levels has provided unique insight into the evolutionary acquisition of immune function. The roles of variable- and intermediate-type immunoglobulin (Ig) domains in direct recognition of ligands and other functions are far wider than previously anticipated. Common mechanisms of multigene family diversification and expansion as well as unique adaptations that relate to function continue to provide unique insight into the numerous patterns, processes and complex interactions that regulate the host response to infectious challenge.
摘要
从遗传、结构和功能水平上对在系统发育上差异很大的物种中的免疫受体进行鉴定，为人们深入了解免疫功能的进化获得提供了独特的视角。可变和中等类型免疫球蛋白 (Ig) 结构域在直接识别配体和其他功能方面的作用远比以前预期的要广泛得多。多基因家族多样化和扩展的常见机制以及与功能相关的独特适应，继续为了解许多调节宿主对感染性挑战的反应的模式、过程和复杂相互作用提供独特的视角。
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