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肺癌手术后未确诊的迟发性乳糜胸伴致命性急性肺血栓栓塞症:1例尸检病例及文献复习

Undiagnosed late-onset chylothorax accompanied by fatal acute pulmonary thromboembolism after surgical treatment of lung cancer: an autopsy case and review of the literature.

作者信息

Ishikawa Takaki, Michiue Tomomi, Zhao Dong, Quan Li, Li Dong-Ri, Maeda Hitoshi

机构信息

Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan.

出版信息

Leg Med (Tokyo). 2010 Jan;12(1):35-8. doi: 10.1016/j.legalmed.2009.10.005. Epub 2009 Dec 8.

Abstract

Late-onset chylothorax is a relatively rare and essentially benign postoperative complication. We describe an autopsy case of undiagnosed hemi-chylothorax accompanied by fatal acute pulmonary thromboembolism after pulmonary resection and lymph node dissection for lung cancer, reviewing the literature. The patient was a 60-year-old woman. She complained of dyspnea on the 20th postoperative day, which gradually increased. The patient suddenly died 2 days later. Autopsy demonstrated right chylothorax (1000 ml), and fatal acute pulmonary thromboembolism, mainly on the left side, originating from the lower extremities. Postoperative chylothorax, causing respiratory and pulmonary circulatory disturbance, may provide an important predisposition to ward fatality due to pulmonary thromboembolism even among those showing a milder type; thus careful management is necessary.

摘要

迟发性乳糜胸是一种相对罕见且本质上为良性的术后并发症。我们报告一例尸检病例,该患者在肺癌肺切除及淋巴结清扫术后发生未被诊断出的半侧乳糜胸,并伴有致命性急性肺血栓栓塞症,同时对相关文献进行回顾。患者为一名60岁女性。她在术后第20天出现呼吸困难,且逐渐加重。两天后患者突然死亡。尸检显示右侧乳糜胸(1000毫升),以及主要发生在左侧、源于下肢的致命性急性肺血栓栓塞症。术后乳糜胸可导致呼吸和肺循环障碍,即使在症状较轻的患者中,也可能是导致肺血栓栓塞症致死的重要诱因;因此需要谨慎处理。

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