Glowacki F, Dharancy S, Noël C, Hazzan M
Pôle de Néphrologie, Hôpital Albert Calmette, CHRU de Lille, Bd du Pr Leclercq, 59037 Lille cedex, France.
Gastroenterol Clin Biol. 2009 Nov;33 Suppl 4:S253-6. doi: 10.1016/S0399-8320(09)73162-8.
Chronic renal dysfunction is a multifactorial and frequent event after organ transplantation. The measurement or the estimation of glomerular filtration rate is essential to detect early progressive renal dysfunction. Proliferation signal inhibitors are nonnephrotoxic immunosuppressive drugs which may be useful to minimize calcineurin inhibitors-related side effects through a conversion strategy. Most studies in the setting of kidney transplantation showed improvement in glomerular filtration rate as high than conversion was early. Proliferation signal inhibitors may be included quickly in new immunosuppressive regimen for liver transplanted patients with chronic renal dysfunction.
慢性肾功能不全是器官移植后常见的多因素事件。肾小球滤过率的测量或估算对于早期发现进行性肾功能不全至关重要。增殖信号抑制剂是一种非肾毒性免疫抑制药物，通过转换策略可用于尽量减少钙调神经磷酸酶抑制剂相关的副作用。大多数肾移植相关研究表明，转换越早，肾小球滤过率改善越高。增殖信号抑制剂可迅速纳入慢性肾功能不全肝移植患者的新免疫抑制方案中。
