[增殖信号抑制剂的副作用及其管理]

[Side effects of proliferation signal inhibitors and their management].

作者信息

Epailly E, Lorho R

机构信息

Service de Chirurgie cardiaque, Les Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital, 67000 Strasbourg, France.

出版信息

Gastroenterol Clin Biol. 2009 Nov;33 Suppl 4:S268-74. doi: 10.1016/S0399-8320(09)73165-3.

DOI:10.1016/S0399-8320(09)73165-3

PMID:20004334

Abstract

Proliferation signal inhibitors (PSI) could help to lower the calcineurine inhibitors level to minimize their toxicity and improve long-term graft survival. Side effects of this drugs are specific and must been known. Hyperlipidemia and cutaneous side-effects are the most frequent, angioedema and interstital pneumonitis the most serious. In majority of cases, early and adapted management could limit the impact of these side effects.

摘要

增殖信号抑制剂（PSI）有助于降低钙调神经磷酸酶抑制剂的水平，以将其毒性降至最低并提高移植物的长期存活率。这类药物的副作用具有特异性，必须有所了解。高脂血症和皮肤副作用最为常见，血管性水肿和间质性肺炎最为严重。在大多数情况下，早期且适当的处理可以限制这些副作用的影响。