Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
Int J Dermatol. 2010 Jan;49(1):91-4. doi: 10.1111/j.1365-4632.2009.04319.x.
Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy. This association has been reported less frequently with tacrolimus.
We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.
Since these drugs are used widely in the pediatric transplantation population, this report serves to heighten awareness of this debilitating phenomenon, and to stress the importance of exercising caution when sirolimus and tacrolimus are administered in combination to pediatric patients.
阿弗他口炎是一种常见的黏膜皮肤疾病，是西罗莫司治疗的公认并发症。这种关联在他克莫司治疗中较少见。
我们报告了一例 11 岁男性患者，患有布加综合征，在免疫抑制治疗从他克莫司改为西罗莫司后，慢性阿弗他溃疡严重恶化。
由于这些药物在儿科移植人群中广泛使用，因此本报告旨在提高对这种使人衰弱现象的认识，并强调在给儿科患者联合使用西罗莫司和他克莫司时要谨慎。
