男性 2 型糖尿病患者的血红蛋白浓度。
Hemoglobin concentration in men with type 2 diabetes mellitus.
机构信息
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kamigyo-ku, Kyoto 602-8566, Japan.
出版信息
Metabolism. 2010 Jun;59(6):808-13. doi: 10.1016/j.metabol.2009.09.028. Epub 2009 Dec 9.
Anemia is a common but often overlooked complication of diabetes. We investigated the relationship between hemoglobin concentration and various factors as well as markers of subclinical atherosclerosis in men with type 2 diabetes mellitus. Hemoglobin concentration was measured in 319 men with type 2 diabetes mellitus. We evaluated the relationship between hemoglobin concentration and various factors including age, body mass index, and glycemic control, as well as between hemoglobin concentration and pulse wave velocity or ankle-brachial index (n = 209) and between hemoglobin concentration and carotid intima-media thickness or plaque score (n = 125). Mean hemoglobin concentration was 14.2 +/- 0.80 g/dL. Body mass index (r = 0.340, P < .0001) and estimated glomerular filtration rate (r = 0.219, P = .0011) were positively associated with hemoglobin concentration, whereas age (r = -0.388, P < .0001), glycated albumin (r = -0.148, P = .0121), serum creatinine concentration (r = -0.206, P = .0019), and log (urinary albumin excretion) (r = -0.188, P = .0010) were negatively associated with hemoglobin concentration. Multiple regression analysis identified age (beta = -0.222, P = .0019), body mass index (beta = 0.145, P = .0432), systolic blood pressure (beta = 0.214, P = .0015), total cholesterol concentration (beta = 0.170, P = .0077), and serum creatinine concentration (beta = -0.181, P = .0045) as independent determinants of hemoglobin concentration. No significant association was observed between hemoglobin concentration and serum erythropoietin concentration (r = -0.079, P = .2980). Negative correlations were found between hemoglobin concentration and pulse wave velocity (r = -0.289, P < .0001) and between hemoglobin concentration and plaque score (r = -0.275, P = .0024). In conclusion, hemoglobin concentration was associated with various factors; and decreased hemoglobin concentration was associated with subclinical markers of atherosclerosis in men with type 2 diabetes mellitus.
贫血是糖尿病常见但常被忽视的并发症。我们研究了血红蛋白浓度与 2 型糖尿病男性的各种因素以及亚临床动脉粥样硬化标志物之间的关系。在 319 名 2 型糖尿病男性中测量了血红蛋白浓度。我们评估了血红蛋白浓度与各种因素之间的关系，包括年龄、体重指数和血糖控制，以及血红蛋白浓度与脉搏波速度或踝臂指数（n = 209）之间的关系，以及血红蛋白浓度与颈动脉内膜中层厚度或斑块评分（n = 125）之间的关系。平均血红蛋白浓度为 14.2 +/- 0.80 g/dL。体重指数（r = 0.340，P <.0001）和估计肾小球滤过率（r = 0.219，P =.0011）与血红蛋白浓度呈正相关，而年龄（r = -0.388，P <.0001）、糖化白蛋白（r = -0.148，P =.0121）、血清肌酐浓度（r = -0.206，P =.0019）和尿白蛋白排泄量的对数（r = -0.188，P =.0010）与血红蛋白浓度呈负相关。多元回归分析确定年龄（β = -0.222，P =.0019）、体重指数（β = 0.145，P =.0432）、收缩压（β = 0.214，P =.0015）、总胆固醇浓度（β = 0.170，P =.0077）和血清肌酐浓度（β = -0.181，P =.0045）是血红蛋白浓度的独立决定因素。血红蛋白浓度与血清促红细胞生成素浓度之间无显著相关性（r = -0.079，P =.2980）。血红蛋白浓度与脉搏波速度呈负相关（r = -0.289，P <.0001），血红蛋白浓度与斑块评分呈负相关（r = -0.275，P =.0024）。总之，血红蛋白浓度与多种因素相关；在 2 型糖尿病男性中，血红蛋白浓度降低与亚临床动脉粥样硬化标志物相关。
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