Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Korean J Intern Med. 2012 Sep;27(3):285-92. doi: 10.3904/kjim.2012.27.3.285. Epub 2012 Sep 1.
BACKGROUND/AIMS: Many studies have demonstrated an association between hemoglobin levels and cardiovascular disease in diabetic patients. The aim of this study was to determine whether there is an association between hemoglobin concentrations and various clinical parameters, including metabolic factors, plasma C-peptide response after a meal tolerance test, and microvascular complications, in Korean patients with type 2 diabetes.
In total, 337 male patients with type 2 diabetes were recruited. All subjects were subjected to a meal tolerance test and underwent assessment of hemoglobin levels, fasting and postprandial β-cell responsiveness, and microvascular complications.
Patients with lower hemoglobin concentrations had a longer duration of diabetes, a lower body mass index, and lower concentrations of total cholesterol, triglycerides, and low-density lipoprotein cholesterol. They also had lower levels of postprandial C-peptide, Δ C-peptide, and postprandial β-cell responsiveness. They had a higher prevalence of retinopathy and nephropathy. In multivariate analyses, there was a significant association between nephropathy and hemoglobin concentration. Also, hemoglobin concentrations were independently associated with Δ C-peptide levels and postprandial β-cell responsiveness.
Hemoglobin concentrations are associated with postprandial C-peptide responses and diabetic nephropathy in patients with type 2 diabetes.
背景/目的：许多研究表明，糖尿病患者的血红蛋白水平与心血管疾病之间存在关联。本研究旨在确定韩国 2 型糖尿病患者的血红蛋白浓度是否与各种临床参数（包括代谢因素、餐后耐糖试验时的血浆 C 肽反应和微血管并发症）存在关联。
共纳入 337 名男性 2 型糖尿病患者。所有患者均接受了耐糖试验，并对血红蛋白水平、空腹和餐后β细胞反应性以及微血管并发症进行了评估。
血红蛋白浓度较低的患者糖尿病病程较长，体重指数较低，总胆固醇、甘油三酯和低密度脂蛋白胆固醇浓度较低。他们的餐后 C 肽、ΔC 肽和餐后β细胞反应性也较低。他们患视网膜病变和肾病的比例更高。多变量分析显示，肾病与血红蛋白浓度有显著关联。此外，血红蛋白浓度与餐后 C 肽水平和餐后β细胞反应性独立相关。
血红蛋白浓度与 2 型糖尿病患者的餐后 C 肽反应和糖尿病肾病有关。
