Department of Psychiatry and Clinical Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Epilepsy Behav. 2010 Jan;17(1):109-19. doi: 10.1016/j.yebeh.2009.11.002. Epub 2009 Dec 9.
Working memory (WM) deficits are considered a core cognitive dysfunction in schizophrenia. To determine cognitive abnormalities in chronic interictal psychosis (CIP), and to assess whether these abnormalities are distinguishable from those seen in schizophrenia in terms of WM deficits, we used magnetoencephalography during a WM task performed by patients with CIP, nonpsychotic epilepsy, and schizophrenia and by healthy subjects. Multiple Source Beamformer and Brain-Voyager were used for analysis. In both patients with CIP and those with schizophrenia, we found dorsolateral prefrontal hyperactivation and left inferior temporal hypoactivation, as indicated by alpha event-related desynchronization and synchronization, respectively. Patients with schizophrenia also showed alpha2 event-related desynchronization in the mid-prefrontal cortex relative to healthy controls. Direct comparison of patients with CIP and schizophrenia rendered no difference in source-power changes. Our findings indicate similar functional cognitive abnormalities in CIP and schizophrenia in the prefrontal and left temporal cortex, which supports the possibility that these disorders share common underlying pathophysiological mechanisms.
工作记忆（WM）缺陷被认为是精神分裂症的核心认知功能障碍。为了确定慢性发作间期精神病（CIP）中的认知异常，并评估这些异常是否在 WM 缺陷方面与精神分裂症区分开来，我们使用磁源性影像技术（MEG）在 WM 任务中对 CIP、非精神病性癫痫和精神分裂症患者以及健康受试者进行了研究。采用多源波束形成器和 Brain-Voyager 进行分析。在 CIP 患者和精神分裂症患者中，我们发现背外侧前额叶过度激活，左侧颞下回活动减弱，这分别表现为 alpha 事件相关去同步化和同步化。与健康对照组相比，精神分裂症患者还表现出中前额皮质的 alpha2 事件相关去同步化。对 CIP 患者和精神分裂症患者进行直接比较，未发现源功率变化的差异。我们的研究结果表明，CIP 和精神分裂症在额叶和左侧颞叶皮层存在相似的功能认知异常，这支持了这些疾病可能具有共同的潜在病理生理机制的可能性。
