Giusti M, Parazzi F, Reitano A, Bolognesi F, Giordano G
Acta Eur Fertil. 1977 Sep;8(3):211-28.
A study has been made of the behaviour of certain hormonal parameters (LH, FSH, PRL, HGH, ACTH, cortisol and testosterone) in five women aged from 17 to 28 years, during two successive menstrual cycles, the first under basal conditions and the second while under treatment with cyproterone acetate (CPA) 100 mg/day), given from the fifth to the twenty-fifth day of the cycle. On the first day of the initial cycle and the twenty-ninth day of the second cycle, the secretion of gonadotropins, prolactin, and somatotropin were measured before and after stimulation with GnRH (50 microgram, i.v.), sulpiride (200 mg, i.m.) or insulin (0.1 U/kg). During treatment with CPA the ovulatory peak of LH was abolished, with a reduction in the levels of gonadotropin and testosterone. No changes were observed for PRL, HGH, ACTH or cortisol. The study of the pituitary reserves showed a reduced response of LH but not of FSH to GnRH. There were no changes in the response of PRL and HGH to stimulation. The data obtained confirm the inhibitory effect of CPA on gonadotropin and testosterone secretion, while the other parameters studied did not vary significantly.
对5名年龄在17至28岁的女性在两个连续月经周期中的某些激素参数（促黄体生成素、促卵泡生成素、催乳素、生长激素、促肾上腺皮质激素、皮质醇和睾酮）的行为进行了研究。第一个周期处于基础状态，第二个周期在从周期的第五天到第二十五天每天服用100毫克醋酸环丙孕酮（CPA）的情况下进行。在初始周期的第一天和第二个周期的第二十九天，在用促性腺激素释放激素（50微克，静脉注射）、舒必利（200毫克，肌肉注射）或胰岛素（0.1单位/千克）刺激之前和之后，测量促性腺激素、催乳素和生长激素的分泌。在用CPA治疗期间，促黄体生成素的排卵高峰消失，促性腺激素和睾酮水平降低。催乳素、生长激素、促肾上腺皮质激素或皮质醇未观察到变化。垂体储备的研究表明，促黄体生成素对促性腺激素释放激素的反应降低，但促卵泡生成素没有。催乳素和生长激素对刺激的反应没有变化。获得的数据证实了CPA对促性腺激素和睾酮分泌的抑制作用，而所研究的其他参数没有显著变化。
