College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, Republic of Korea.
Neurosci Lett. 2010 Jan 29;469(3):298-302. doi: 10.1016/j.neulet.2009.12.009. Epub 2009 Dec 11.
Noise-induced hearing loss (NIHL) has been thought to primarily involve damage to the sensory hair cells of the cochlea via mechanical and metabolic mechanisms. This study examined the effects of baicalin, baicalein, and Scutellaria baicalensis (SB) extract against NIHL in a mouse model. Mice received oral treatment with SB, baicalin, baicalein beginning 30 min prior to noise exposure and continuing once daily throughout the study. Hearing threshold shift was assessed by auditory brain stem responses for 35 days following noise exposure. Central auditory function was evaluated by auditory middle latency responses. Cochlear function was determined based on transient evoked otoacoustic emissions. SB significantly reduced threshold shift, central auditory function damage, and cochlear function deficits, suggesting that SB may protect auditory function in NIHL and that the active constituent may be a flavonoid, baicalein.
噪声性听力损失（NIHL）被认为主要通过机械和代谢机制导致耳蜗感觉毛细胞损伤。本研究在小鼠模型中研究了黄芩苷、黄芩素和黄芩（SB）提取物对 NIHL 的作用。小鼠在噪声暴露前 30 分钟开始接受 SB、黄芩苷、黄芩素的口服治疗，并在整个研究期间每天一次。噪声暴露后 35 天通过听觉脑干反应评估听力阈移。通过听觉中潜伏期反应评估中枢听觉功能。根据瞬态诱发耳声发射确定耳蜗功能。SB 可显著降低阈移、中枢听觉功能损伤和耳蜗功能缺陷，提示 SB 可能对 NIHL 中的听觉功能具有保护作用，其活性成分可能是黄酮类化合物黄芩素。
