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通过神经元基因调控对感音神经性听力损失的影响。

Effects of on Sensorineural Hearing Loss via Neuronal Gene Regulation.

机构信息

Department of Oriental Medicine Biotechnology, Graduate School of Biotechnology, Kyung Hee University, Global Campus, Yongin 17104, Republic of Korea.

Invivotec Co., Ltd., Seongnam 13449, Republic of Korea.

出版信息

Nutrients. 2024 Aug 15;16(16):2716. doi: 10.3390/nu16162716.

DOI:10.3390/nu16162716
PMID:39203853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357119/
Abstract

Sensorineural hearing loss (SNHL), characterized by damage to the inner ear or auditory nerve, is a prevalent auditory disorder. This study explores the potential of (CAE) as a therapeutic agent for SNHL. In vivo experiments were conducted using zebrafish and mouse models. Zebrafish with neomycin-induced ototoxicity were treated with CAE, resulting in otic hair cell protection with an EC of 0.49 µg/mL and a therapeutic index of 1020. CAE treatment improved auditory function and protected cochlear sensory cells in a mouse model after noise-induced hearing loss (NIHL). RNA sequencing of NIHL mouse cochleae revealed that CAE up-regulates genes involved in neurotransmitter synthesis, secretion, transport, and neuronal survival. Real-time qPCR validation showed that NIHL decreased the mRNA expression of genes related to neuronal function, such as , , , , , and , while the CAE treatment significantly elevated these levels. In conclusion, our findings provide strong evidence that CAE protects against hearing loss by promoting sensory cell protection and enhancing the expression of genes critical for neuronal function and survival.

摘要

感音神经性听力损失（SNHL），其特征是内耳或听神经损伤，是一种常见的听觉障碍。本研究探讨了 CAE 作为 SNHL 治疗剂的潜力。使用斑马鱼和小鼠模型进行了体内实验。用 CAE 处理新霉素诱导的耳毒性斑马鱼，导致毛细胞保护，EC 为 0.49µg/mL，治疗指数为 1020。CAE 治疗可改善噪声诱导听力损失（NIHL）后小鼠的听觉功能并保护耳蜗感觉细胞。NIHL 小鼠耳蜗的 RNA 测序显示，CAE 上调了参与神经递质合成、分泌、转运和神经元存活的基因。实时 qPCR 验证表明，NIHL 降低了与神经元功能相关的基因（如、、、、、和）的 mRNA 表达，而 CAE 治疗则显著提高了这些基因的表达水平。总之，我们的研究结果提供了有力的证据，表明 CAE 通过促进感觉细胞保护和增强对神经元功能和存活至关重要的基因的表达来对抗听力损失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/c8bbbdec693a/nutrients-16-02716-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/9e4ada1fae4e/nutrients-16-02716-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/526af2bb0a6a/nutrients-16-02716-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/e022c6ba1222/nutrients-16-02716-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/0c174e2d3563/nutrients-16-02716-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/c8bbbdec693a/nutrients-16-02716-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/9e4ada1fae4e/nutrients-16-02716-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/54bd87249550/nutrients-16-02716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/e20cb4d909e6/nutrients-16-02716-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/5cd73dcbd206/nutrients-16-02716-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/526af2bb0a6a/nutrients-16-02716-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/e022c6ba1222/nutrients-16-02716-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/0c174e2d3563/nutrients-16-02716-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3069/11357119/c8bbbdec693a/nutrients-16-02716-g008.jpg

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