INSERM U 872, Centre de Recherche des Cordeliers, Paris, F-75006, France.
Autoimmun Rev. 2010 Apr;9(6):441-8. doi: 10.1016/j.autrev.2009.12.004. Epub 2010 Jan 13.
Kawasaki disease (KD) is an acute febrile childhood vasculitis, associated with the development of coronary artery abnormalities in 25-30% of untreated patients. The aetiopathogenesis is not well known but it is accepted that an undefined infectious trigger in genetically predisposed individuals results in the disease. KD is characterized by an endothelial cell injury, which could be due to abnormal cytokine production and to generation of cytotoxic antibodies against the endothelial cells. Intravenous immunoglobulin IVIG is an effective treatment in preventing the occurrence of coronary artery abnormalities in KD. Several mechanisms may explain the anti-inflammatory effects of IVIG in this disease. They include modification of the cytokine balance, and alteration on both the differentiation and the function of monocytes/macrophages, neutrophils and lymphocytes.
川崎病（KD）是一种急性发热性儿童血管炎，未经治疗的患者中有 25-30%会出现冠状动脉异常。其发病机制尚不清楚，但人们普遍认为，遗传易感个体中存在未明的感染触发因素，导致该病发生。KD 的特征是内皮细胞损伤，这可能是由于细胞因子产生异常和针对内皮细胞的细胞毒性抗体产生所致。静脉注射免疫球蛋白（IVIG）是预防 KD 患者发生冠状动脉异常的有效治疗方法。多种机制可能解释 IVIG 在该病中的抗炎作用。这些机制包括细胞因子平衡的改变，以及单核细胞/巨噬细胞、中性粒细胞和淋巴细胞的分化和功能的改变。
