Nonoyama S
Department of Pediatrics, Faculty of Medicine, Tokyo Medical and Dental University.
Acta Paediatr Jpn. 1991 Dec;33(6):752-5. doi: 10.1111/j.1442-200x.1991.tb02604.x.
Kawasaki disease is an acute febrile disease causing vasculitis, which may lead to as severe a complication as myocardial infarction. This disease is characterized by marked activation of the immune system, including elevation of various cytokines, polyclonal B cell activation, and decrease of CD8+ cells. The high levels of cytokines induce adhesion molecules and a new antigen on endothelial cells. As a result, the immune cells bind to the endothelium and the activated immune cells produce cytotoxic antibodies against the new antigen on the endothelial cells. Thus, the activated immune system is involved in the endothelial cell injury. IVIG (intravenous immunoglobulin) therapy suppresses the activated immune system and reduces the endothelial cell damage.
川崎病是一种引起血管炎的急性发热性疾病，可能导致如心肌梗死这样严重的并发症。这种疾病的特征是免疫系统显著激活，包括各种细胞因子升高、多克隆B细胞激活以及CD8+细胞减少。高水平的细胞因子诱导内皮细胞上的黏附分子和一种新抗原。结果，免疫细胞与内皮细胞结合，活化的免疫细胞产生针对内皮细胞上新抗原的细胞毒性抗体。因此，活化的免疫系统参与了内皮细胞损伤。静脉注射免疫球蛋白（IVIG）疗法可抑制活化的免疫系统并减少内皮细胞损伤。
