University of California San Diego Department of Pathology, San Diego, CA 92103-8720, USA.
Hum Pathol. 2010 Mar;41(3):447-51. doi: 10.1016/j.humpath.2009.09.002. Epub 2009 Dec 11.
Adult nesidioblastosis is an uncommon cause of hyperinsulinemic hypoglycemia characterized by diffuse islet hyperplasia with beta-cell hypertrophy and atypia. The cause of nesidioblastosis in adults is unclear but may be different from nesidioblastosis in infants. In contrast to infants, a focal form of adult nesidioblastosis (ie, "nesidioblastoma") has not been documented, although proposed. We report a 44-year-old man with symptomatic hypoglycemia and localized nesidioblastosis treated with surgical enucleation resulting in normalization of blood glucose. Postoperative euglycemia has persisted in this patient to date (4 months at the time of manuscript submission).
成人胰岛细胞瘤是一种罕见的引起高胰岛素血症低血糖的病因，其特征为弥漫性胰岛细胞增生伴β细胞肥大和异型性。成人胰岛细胞瘤的病因尚不清楚，但可能与婴儿期的胰岛细胞瘤不同。与婴儿不同，成人胰岛细胞瘤（即“胰岛细胞瘤”）无局灶性报道，尽管有报道提出过这种可能性。我们报告了一例 44 岁男性，表现为症状性低血糖和局灶性胰岛细胞瘤，经手术摘除法治疗后，血糖恢复正常。截至目前（在提交手稿时为 4 个月），该患者术后血糖一直保持正常。
