• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

局灶性胰岛细胞增殖症的诊断与定位困难：（68）镓 - DOTA - D - 苯丙氨酸（1） - 酪氨酸（3） - 奥曲肽PET扫描的临床意义

Difficult diagnosis and localization of focal nesidioblastosis: clinical implications of (68)Gallium-DOTA-D-Phe(1)-Tyr(3)-octreotide PET scanning.

作者信息

Kim Jae Ri, Jang Jin-Young, Shin Yong Chan, Cho Young Min, Kim Hongbeom, Kwon Wooil, Han Young Min, Kim Sun-Whe

机构信息

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Ann Surg Treat Res. 2016 Jul;91(1):51-5. doi: 10.4174/astr.2016.91.1.51. Epub 2016 Jun 30.

DOI:10.4174/astr.2016.91.1.51
PMID:27433465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4942539/
Abstract

Focal nesidioblastosis is a rare cause of endogenous hyperinsulinemic hypoglycemia in adults. Because it is difficult to localize and detect with current imaging modalities, nesidioblastosis is challenging for biliary-pancreatic surgeons. (68)Gallium-DOTA-D-Phe(1)-Tyr(3)-octreotide PET scanning and (111)indium-pentetreotide diethylene triamine pentaacetic acid octreotide scanning may be superior to conventional imaging modalities in determining the localization of nesidioblastosis. We report the successful surgical treatment of a 54-year-old woman with focal hyperplasia of the islets of Langerhans, who experienced frequent hypoglycemic symptoms and underwent various diagnostic examinations with different results.

摘要

局灶性胰岛细胞增殖症是成人内源性高胰岛素血症性低血糖症的罕见病因。由于目前的成像方式难以定位和检测到它，胰岛细胞增殖症对肝胆胰外科医生来说具有挑战性。（68）镓 - DOTA - D - 苯丙氨酸（1） - 酪氨酸（3） - 奥曲肽正电子发射断层扫描和（111）铟 - 喷替酸奥曲肽扫描在确定胰岛细胞增殖症的定位方面可能优于传统成像方式。我们报告了一例成功接受手术治疗的54岁女性，她患有朗格汉斯胰岛局灶性增生，频繁出现低血糖症状，并接受了各种诊断检查，结果各异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/02ffb9e276f3/astr-91-51-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/a23de17a4271/astr-91-51-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/ff95ae4a1557/astr-91-51-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/98fff66cc906/astr-91-51-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/f53289e58589/astr-91-51-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/02ffb9e276f3/astr-91-51-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/a23de17a4271/astr-91-51-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/ff95ae4a1557/astr-91-51-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/98fff66cc906/astr-91-51-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/f53289e58589/astr-91-51-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/4942539/02ffb9e276f3/astr-91-51-g005.jpg

相似文献

1
Difficult diagnosis and localization of focal nesidioblastosis: clinical implications of (68)Gallium-DOTA-D-Phe(1)-Tyr(3)-octreotide PET scanning.局灶性胰岛细胞增殖症的诊断与定位困难：（68）镓 - DOTA - D - 苯丙氨酸（1） - 酪氨酸（3） - 奥曲肽PET扫描的临床意义
Ann Surg Treat Res. 2016 Jul;91(1):51-5. doi: 10.4174/astr.2016.91.1.51. Epub 2016 Jun 30.
2
Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report.双核素示踪正电子发射断层扫描/计算机断层扫描辅助诊断胰腺局灶性胰岛细胞增殖症：一例报告
Exp Ther Med. 2023 Nov 28;27(1):42. doi: 10.3892/etm.2023.12330. eCollection 2024 Jan.
3
Relative quantification of indium-111 pentetreotide and gallium-68 DOTATOC uptake in the thyroid gland and association with thyroid pathologies.
Thyroid. 2009 Apr;19(4):381-9. doi: 10.1089/thy.2008.0389.
4
Adult-Onset Focal Nesidioblastosis With Nodular Formation Mimicking Insulinoma.成年发病的局灶性胰岛细胞增生伴结节形成，酷似胰岛素瘤。
J Endocr Soc. 2021 Dec 11;6(1):bvab185. doi: 10.1210/jendso/bvab185. eCollection 2022 Jan 1.
5
Evaluation of positron emission tomography imaging using [68Ga]-DOTA-D Phe(1)-Tyr(3)-Octreotide in comparison to [111In]-DTPAOC SPECT. First results in patients with neuroendocrine tumors.使用[68Ga]-DOTA-D Phe(1)-Tyr(3)-奥曲肽的正电子发射断层扫描成像与[111In]-DTPA-奥曲肽单光子发射计算机断层扫描的比较评估。神经内分泌肿瘤患者的初步结果。
Mol Imaging Biol. 2003 Jan-Feb;5(1):42-8. doi: 10.1016/s1536-1632(03)00038-6.
6
[Symptoms and early diagnostic possibilities of pancreatic endocrine cells hyperplasia (nesidioblastosis)].胰腺内分泌细胞增生（胰岛细胞增殖症）的症状及早期诊断可能性
Przegl Lek. 2012;69(1):9-14.
7
Striking Visualization of Diffuse Congenital Nesidioblastosis on Ga-68 DOTATATE PET/CT.Ga-68 DOTATATE PET/CT对弥漫性先天性胰岛细胞增殖症的显著可视化
Mol Imaging Radionucl Ther. 2019 Jun 24;28(2):83-85. doi: 10.4274/mirt.galenos.2018.38039.
8
Nesidioblastosis. A case of hyperplasia of the islets of Langerhans in the adult.胰岛细胞增生症。成人胰岛兰氏小岛增生症一例。
Pancreatology. 2013 Sep-Oct;13(5):544-8. doi: 10.1016/j.pan.2013.06.009. Epub 2013 Jul 5.
9
BYPASS-OMA: Hypoglycemic Hyperinsulinemic Nesidioblastosis after Gastric Bypass Surgery-A Case Report and Review of the Literature.胃旁路术后低血糖高胰岛素血症性胰岛细胞增殖症——一例报告并文献复习
Case Rep Endocrinol. 2022 Dec 22;2022:5472304. doi: 10.1155/2022/5472304. eCollection 2022.
10
Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis.
Ann Nucl Med. 2009 Jul;23(5):497-9. doi: 10.1007/s12149-009-0252-6. Epub 2009 Apr 22.

引用本文的文献

1
Use of Translational Science, Continuous Glucose Monitoring in the Primary Care Setting for Management of Nesidioblastosis: A Case Report and Literature Review.在基层医疗环境中运用转化科学及持续葡萄糖监测来管理胰岛细胞增殖症：一例病例报告及文献综述
Cureus. 2024 Apr 30;16(4):e59388. doi: 10.7759/cureus.59388. eCollection 2024 Apr.
2
Circularity of islets is a distinct marker for the pathological diagnosis of adult non-neoplastic hyperinsulinemic hypoglycemia using surgical specimens.胰岛的环状形态是使用手术标本进行成人非肿瘤性高胰岛素血症性低血糖症病理诊断的一个显著标志物。
Diagn Pathol. 2023 Oct 20;18(1):115. doi: 10.1186/s13000-023-01403-y.
3

本文引用的文献

1
The role of 68Ga-DOTATATE PET in patients with neuroendocrine tumors and negative or equivocal findings on 111In-DTPA-octreotide scintigraphy.68Ga-DOTATATE PET 在 111In-DTPA-octreotide 闪烁扫描阴性或不确定的神经内分泌肿瘤患者中的作用。
J Nucl Med. 2010 Jun;51(6):875-82. doi: 10.2967/jnumed.109.066134. Epub 2010 May 19.
2
Case report: focal nesidioblastosis ("nesidioblastoma") in an adult.病例报告：成人局灶性胰岛细胞瘤（“胰岛细胞瘤”）。
Hum Pathol. 2010 Mar;41(3):447-51. doi: 10.1016/j.humpath.2009.09.002. Epub 2009 Dec 11.
3
Nesidioblastoma, the islet tumor of the pancreas.
An Uncommon Cause of Recurrent Presyncope, Dizziness, and Tachycardia: A Case Report of Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS).
复发性前驱晕厥、头晕和心动过速的罕见病因：弥漫性成人发病的胰岛细胞增殖症/非胰岛素瘤胰腺源性低血糖综合征（NIPHS）病例报告
Biomedicines. 2023 Jun 17;11(6):1741. doi: 10.3390/biomedicines11061741.
4
Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia.弥漫性成人起病的胰岛细胞增殖症/非胰岛素瘤性胰源性低血糖综合征（NIPHS）：高胰岛素血症性低血糖罕见病因的文献综述
Biomedicines. 2023 Jun 16;11(6):1732. doi: 10.3390/biomedicines11061732.
胰岛细胞瘤，胰腺的胰岛肿瘤。
Am J Pathol. 1938 Mar;14(2):125-134.5.
4
Localization of insulinomas to regions of the pancreas by intraarterial calcium stimulation: the NIH experience.通过动脉内钙刺激将胰岛素瘤定位到胰腺区域：美国国立卫生研究院的经验。
J Clin Endocrinol Metab. 2009 Apr;94(4):1074-80. doi: 10.1210/jc.2008-1986. Epub 2009 Feb 3.
5
Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours.68Ga-DOTATOC正电子发射断层扫描（PET）与111铟-二乙三胺五醋酸奥曲肽（Octreoscan）单光子发射计算机断层扫描（SPECT）在神经内分泌肿瘤患者中的比较。
Eur J Nucl Med Mol Imaging. 2007 Oct;34(10):1617-26. doi: 10.1007/s00259-007-0450-1. Epub 2007 May 23.
6
Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome.成人胰岛增生：术前诊断非胰岛素瘤胰腺源性低血糖综合征的挑战。
World J Surg. 2006 May;30(5):670-9. doi: 10.1007/s00268-005-0543-6.
7
Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use.用于闪烁显像和放射治疗的生长抑素放射性示踪剂对人类生长抑素受体亚型SST1 - SST5的亲和力图谱。
Eur J Nucl Med. 2000 Mar;27(3):273-82. doi: 10.1007/s002590050034.
8
Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene.谷氨酸脱氢酶基因调控突变婴儿的高胰岛素血症和高氨血症
N Engl J Med. 1998 May 7;338(19):1352-7. doi: 10.1056/NEJM199805073381904.
9
Localization of islet cell tumors.
Gastroenterol Clin North Am. 1989 Dec;18(4):793-804.
10
Insulinomas: localization with selective intraarterial injection of calcium.胰岛素瘤：通过选择性动脉内注射钙进行定位
Radiology. 1991 Jan;178(1):237-41. doi: 10.1148/radiology.178.1.1984311.