Department of Chemistry, Kakatiya University, Warangal-506 009, India.
Eur J Med Chem. 2010 Mar;45(3):1200-5. doi: 10.1016/j.ejmech.2009.11.038. Epub 2009 Nov 26.
A new series of indolo[1,2-c]quinazoline derivatives were prepared in good yield through reaction of 2-(o-aminophenyl)indole with a variety of arylaldehydes. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR and mass spectral studies and elemental analysis. All the title compounds were investigated for their activity against certain strains of Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Streptococcus pyogenes), Gram-negative bacteria (Salmonella typhimurium, Escherichia coli and Klebsiella pneumonia) and pathogenic Fungi (Aspergillus niger, Candida albicans and Trichoderma viridae). Ampicillin and ketoconazole were used as reference compounds. The results revealed that some of synthesized compounds displayed marked activity against all the tested microorganisms.
通过 2-(o-氨基苯基)吲哚与各种芳醛的反应，制备了一系列新的吲唑并[1,2-c]喹唑啉衍生物，收率良好。通过 IR、(1)H NMR、(13)C NMR 和质谱研究以及元素分析确认了新合成化合物的结构。所有标题化合物均针对某些革兰氏阳性菌（金黄色葡萄球菌、枯草芽孢杆菌和化脓链球菌）、革兰氏阴性菌（鼠伤寒沙门氏菌、大肠杆菌和肺炎克雷伯菌）和致病性真菌（黑曲霉、白色念珠菌和绿僵菌）进行了活性测试。氨苄西林和酮康唑用作参考化合物。结果表明，一些合成化合物对所有测试的微生物均表现出显著的活性。
