从脱氢枞酸中合成新型 1H-二苯并[a,c]咔唑类化合物及其抗菌活性。
Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid.
机构信息
Department of Forestry Chemical Engineering, College of Chemical Engineering, Nanjing Forestry University, 149, Longpan Road, Nanjing 210037, PR China.
出版信息
Eur J Med Chem. 2010 Oct;45(10):4692-6. doi: 10.1016/j.ejmech.2010.07.038. Epub 2010 Jul 24.
A series of novel 1H-dibenzo[a,c]carbazole derivatives were synthesized in good yield through reaction of methyl 7-oxo-dehydroabietate with a variety of substituted phenylhydrazines. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, MS spectral studies and elemental analysis. All compounds were investigated for their activity against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens) and three fungi (Trichophyton rubrum, Candida albicans and Aspergillus niger). Among the compound tested, 6d, 6e, 6f and 6m exhibited pronounced antibacterial activities and 6e and 6m also showed moderate antifungal activities. Particularly, 6d exhibited stronger antibacterial activity against B. subtilis comparable to positive control.
一系列新型 1H-二苯并[a,c]咔唑衍生物通过甲酯 7-氧代去氢枞酸与各种取代苯肼的反应高产率合成。新合成化合物的结构通过 IR、（1）H NMR、MS 谱研究和元素分析得到证实。所有化合物均针对四种细菌（枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌和荧光假单胞菌）和三种真菌（红色毛癣菌、白色念珠菌和黑曲霉）进行了活性测试。在所测试的化合物中，6d、6e、6f 和 6m 表现出明显的抗菌活性，6e 和 6m 还表现出中等的抗真菌活性。特别是 6d 对枯草芽孢杆菌的抗菌活性比阳性对照更强。
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