Faropoulos K, Apostolakis E
Neurosurgery Department, University Hospital of Patras, University Campus, Rio, Patras Achaia 26504, Greece.
Transplant Proc. 2009 Dec;41(10):4114-9. doi: 10.1016/j.transproceed.2009.09.087.
The need for lung grafts is currently greater than ever. Unfortunately, the availability of grafts is insufficient for this demand. So we are forced to request organs for transplantation in the "waste bin." One possible solution to this problem may be the use of grafts from brain-dead patients. Sadly brain death is followed by devastating hemodynamic, inflammatory, and neurohumoral reactions in the potential donor which not only inflict direct damage, but also induce activation of the immune system which can cause rejection or even graft failure. Therefore, various groups have examined measures to prevent this outcome. In this review, we attempt to reconstruct the events that follow brain death, suggesting an algorithm to prevent a brain-dead patient's lungs from further damage. Finally, we are proposing potential measures of graft's protection of further investigation.
目前对肺移植的需求比以往任何时候都大。不幸的是，可用于移植的肺源不足以满足这种需求。因此，我们被迫在“垃圾桶”中寻求移植器官。解决这个问题的一个可能办法是使用脑死亡患者的肺源。遗憾的是，脑死亡后潜在供体中会出现严重的血流动力学、炎症和神经体液反应，这不仅会造成直接损害，还会激活免疫系统，进而导致排斥反应甚至移植失败。因此，多个研究团队都在探索预防这种情况的措施。在这篇综述中，我们试图梳理脑死亡后的一系列事件，提出一种算法以防止脑死亡患者的肺进一步受损。最后，我们提出了一些有待进一步研究的肺源保护潜在措施。
