骨髓来源的间充质干细胞与调节性T细胞扩增相关联，可抑制大鼠肝移植的急性排斥反应。
Bone marrow-derived mesenchymal stem cells inhibit acute rejection of rat liver allografts in association with regulatory T-cell expansion.
作者信息
Wang Y, Zhang A, Ye Z, Xie H, Zheng S
机构信息
Key Laboratory of Multi-Organ Combined Transplantation, National Ministry of Health, Key Laboratory of Organ Transplantation, Zhejiang Province, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
出版信息
Transplant Proc. 2009 Dec;41(10):4352-6. doi: 10.1016/j.transproceed.2009.08.072.
Bone marrow-derived mesenchymal stem cells (MSCs) exhibit immunosuppressive functions in vitro and in vivo. We investigated the immunoregulatory effects of rat MSCs in a model of allogeneic liver transplantation. Brown Norway rats received livers from inbred Lewis rats, and at designated intervals, infusions of MSCs derived from recipient, donor, or third-party rats. Allograft rejection and recipient survival rates were recorded. In particular, changes in circulating regulatory T cells (Tregs) were measured. After administration of MSCs derived from each of the 3 strains, allograft recipients demonstrated markedly longer survival compared with control animals. Histologic analysis revealed significant inhibition of allograft rejection. The MSCs induced generation of CD4+CD25+Foxp3+ Tregs. We concluded that MSCs inhibit acute rejection of allografts after liver transplantation, and propose that the immunoregulatory effects of MSCs are associated with expansion of Tregs.
骨髓间充质干细胞（MSCs）在体内外均表现出免疫抑制功能。我们在同种异体肝移植模型中研究了大鼠MSCs的免疫调节作用。棕色挪威大鼠接受近交系Lewis大鼠的肝脏，并在指定时间间隔输注来自受体、供体或第三方大鼠的MSCs。记录同种异体移植物排斥反应和受体存活率。特别地，测定循环调节性T细胞（Tregs）的变化。在给予来自3个品系中每个品系的MSCs后，与对照动物相比，同种异体移植物受体的存活时间明显延长。组织学分析显示同种异体移植物排斥反应受到显著抑制。MSCs诱导产生CD4+CD25+Foxp3+ Tregs。我们得出结论，MSCs可抑制肝移植后同种异体移植物的急性排斥反应，并提出MSCs的免疫调节作用与Tregs的扩增有关。
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