Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.
Department of Nephrology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, P. R. China.
Stem Cell Res Ther. 2024 Sep 27;15(1):320. doi: 10.1186/s13287-024-03943-6.
Although liver transplantation (LT) is an effective strategy for end-stage liver diseases, the shortage of donor organs and the immune rejection hinder its widespread implementation in clinical practice. Mesenchymal stem cells (MSCs) transplantation offers a promising approach for patients undergoing liver transplantation due to their immune regulatory capabilities, hepatic protection properties, and multidirectional differentiation potential. In this review, we summarize the potential applications of MSCs transplantation in various LT scenarios. MSCs transplantation has demonstrated effectiveness in alleviating hepatic ischemia-reperfusion injury, enhancing the viability of liver grafts, preventing acute graft-versus-host disease, and promoting liver regeneration in split LT therapy. We also discuss the clinical progress, and explore the immunomodulatory functions of MSCs in response to both adaptive and innate immune responses. Furthermore, we emphasize the interactions between MSCs and different immune cells, including T cells, B cells, plasma cells, natural killer cells, dendritic cells, Kupffer cells, and neutrophils, to provide new insights into the immunomodulatory properties of MSCs in adoptive cell therapy.
虽然肝移植（LT）是治疗终末期肝病的有效策略，但供体器官短缺和免疫排斥阻碍了其在临床实践中的广泛应用。间充质干细胞（MSCs）移植因其具有免疫调节能力、肝保护特性和多向分化潜能，为接受肝移植的患者提供了一种有前途的治疗方法。在这篇综述中，我们总结了 MSCs 移植在各种 LT 情况下的潜在应用。MSCs 移植已被证明可有效减轻肝缺血再灌注损伤，提高肝移植物的存活率，预防急性移植物抗宿主病，并促进劈离式 LT 治疗中的肝再生。我们还讨论了临床进展，并探讨了 MSCs 对适应性和固有免疫反应的免疫调节功能。此外，我们强调了 MSCs 与不同免疫细胞（包括 T 细胞、B 细胞、浆细胞、自然杀伤细胞、树突状细胞、枯否细胞和中性粒细胞）之间的相互作用，以提供对 MSCs 在过继细胞治疗中的免疫调节特性的新见解。
