Escorsell Mañosa Angels, Mas Ordeig Antoni
UCI-Institut de Malalties Digestives i Metabòliques, Hospital Clínic, IDIBAPS, Universitat de Barcelona, CIBERehd, Barcelona, España.
Gastroenterol Hepatol. 2010 Feb;33(2):126-34. doi: 10.1016/j.gastrohep.2009.10.003. Epub 2009 Dec 14.
Acute-on-Chronic Liver Failure (ACLF) is a recently introduced term defined as severe acute deterioration of an established liver disease. This entity usually develops after an acute insult. The main clinical manifestations are hepatorenal syndrome, hepatic encephalopathy and organ failure, with a high risk of death in the short term. The true incidence of ACLF remains difficult to determine due to confusions surrounding the definition of this entity, but seems to be 40% at 5 years in patients with advanced cirrhosis, which translates into 4,000 cases in Europe within this time span. The treatment of choice is liver transplantation. However, due to the shortage of suitable organs and morbidity and mortality in these patients, other options must be used.
慢加急性肝衰竭（ACLF）是一个最近提出的术语，定义为已有的肝脏疾病出现严重急性恶化。这种情况通常在急性损伤后发生。主要临床表现为肝肾综合征、肝性脑病和器官衰竭，短期内死亡风险很高。由于围绕该实体定义存在混淆，ACLF的真实发病率仍难以确定，但在晚期肝硬化患者中5年发病率似乎为40%，这意味着在此时间段内欧洲有4000例病例。治疗的首选方法是肝移植。然而，由于合适器官短缺以及这些患者的发病率和死亡率，必须采用其他治疗选择。
