Wnt 信号与初级体轴的极性。

Wnt signaling and the polarity of the primary body axis.

机构信息

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

出版信息

Cell. 2009 Dec 11;139(6):1056-68. doi: 10.1016/j.cell.2009.11.035.

DOI:10.1016/j.cell.2009.11.035

PMID:20005801

Abstract

How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (protostomes) suggest that Wnt signaling through beta-catenin controls posterior identity during body plan formation in most bilaterally symmetric animals. Wnt signaling also influences primary axis polarity of pre-bilaterian animals, indicating that an axial patterning role for Wnt signaling predates the evolution of bilaterally symmetric animals. The use of posterior Wnt signaling and anterior Wnt inhibition might be a unifying principle of body plan development in most animals.

摘要

动物如何建立和塑造初级体轴是生物学中最基本的问题之一。来自不同后口动物（青蛙、鱼、老鼠和文昌鱼）和扁形动物（原口动物）的数据表明，β-连环蛋白介导的 Wnt 信号在大多数左右对称动物的体节形成过程中控制着后体的身份。Wnt 信号也影响前两侧对称动物的初级轴极性，表明 Wnt 信号的轴向模式作用早于两侧对称动物的进化。后部 Wnt 信号的使用和前部 Wnt 抑制可能是大多数动物体节发育的统一原则。