Nanista Elise McCollough, Poythress Landon Elizabeth, Skipper Isabell Reese, Haskins Trevor, Cora Marieher Felix, Rozario Tania
University of Georgia, Athens, GA, USA.
University of Puerto Rico-Cayey, PR, USA.
bioRxiv. 2025 Mar 13:2025.03.11.642590. doi: 10.1101/2025.03.11.642590.
Competence to regenerate lost tissues varies widely across species. The rat tapeworm, , undergoes continual cycles of shedding and regenerating thousands of reproductive segments to propagate the species. Despite its prowess, can only regenerate posteriorly from a singular tissue: the neck or germinative region (GR). What cells and signaling pathways restrict regeneration competence to the GR? In this study, we show that the head regulates regeneration-competence by promoting maintenance of the GR and inhibiting proglottid formation in a distance-dependent manner. Anterior-posterior (A-P) patterning within the GR provide local signals that mediate these head-dependent responses. is necessary for stem cell maintenance, proliferation and proglottidization. On the other hand, is necessary for maintaining the GR at its proper length. Our study demonstrates that the head organizes a balance of pro- and anti-regeneration signals that must be integrated together and therefore control competence to regenerate.
不同物种再生受损组织的能力差异很大。大鼠绦虫会经历持续的脱落和再生数千个生殖节片的循环，以繁衍物种。尽管它有这种能力，但只能从单一组织——颈部或生发区（GR）向后再生。哪些细胞和信号通路将再生能力限制在生发区呢？在这项研究中，我们表明头部通过促进生发区的维持并以距离依赖的方式抑制节片形成来调节再生能力。生发区内的前后（A-P）模式提供了介导这些依赖头部反应的局部信号。[此处原文缺失具体基因名称]对于干细胞的维持、增殖和节片化是必需的。另一方面，[此处原文缺失具体基因名称]对于将生发区维持在适当长度是必需的。我们的研究表明，头部组织了促进再生和抑制再生信号的平衡，这些信号必须整合在一起，从而控制再生能力。
