Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Neuron. 2009 Dec 10;64(5):624-31. doi: 10.1016/j.neuron.2009.10.018.
Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor readers. Prior to instruction, poor readers had significantly lower FA than good readers in a region of the left anterior centrum semiovale. The instruction resulted in a change in white matter (significantly increased FA), and in the very same region. The FA increase was correlated with a decrease in radial diffusivity (but not with a change in axial diffusivity), suggesting that myelination had increased. Furthermore, the FA increase was correlated with improvement in phonological decoding ability, clarifying the cognitive locus of the effect. The results demonstrate the capability of a behavioral intervention to bring about a positive change in cortico-cortical white matter tracts.
神经影像学研究使用弥散张量成像（DTI）揭示了阅读困难者大脑白质区域的微观结构组织减少（分数各向异性或 FA 值较低）。我们研究了 100 小时的强化矫正教学是否会影响 8 至 10 岁阅读困难者的白质。在教学之前，阅读困难者在左前半卵圆中心的一个区域的 FA 值明显低于阅读能力良好者。教学导致白质发生变化（FA 值显著增加），并且在同一区域。FA 值的增加与径向扩散率的降低相关（但与轴向扩散率的变化无关），这表明髓鞘形成增加了。此外，FA 值的增加与语音解码能力的提高相关，明确了这种影响的认知定位。研究结果表明，行为干预有能力带来皮质间白质束的积极变化。
